Class: 3D Culture/Scaffold (92)
Cell delivery patch for myocardial tissue engineering
Patent Number: 7,396,537Various types of stem cell therapeutics are being attempted for cardiac conditions. On the one hand, it is known that infarcts induce mobilization of stem cells, and that this may be part of an endogenous regenerative response. Accordingly, the intravenous administration of mesenchymal stem cells has demonstrated a regenerative...
Hedgehog signaling promotes the formation of three dimensional cartilage matrices
Patent Number: 7,160,725It is known that hedgehog proteins are involved in pattern specification during embryogenesis. The possibility of modulating the hedgehog signalling pathway for regulation of stem cell activity was previously patented for hematopoietic stem cells, neural stem cells and...
Cell delivery system comprising a fibrous matrix and cells
Patent Number: 7,323,190The current patent covers the delivery of cells using a matrix that is fibrous and the fibers are between 10 nanometers to 1 micrometer in diameter. The fibers are made in such a manner so that they are in contact with the cells. In some of the claims the fibers are comprised of polymers, one type of polymer covered is a linear aliphatic polyester. A specific type of linear aliphatic...
Instrument for regenerating living organism tissue or organ
Patent Number: 6953482Essentially the invention is a scaffold with a tube-like feature in which cells may be grown outside of the body to form an organ or tissue, and then will be used for implantation into the host. The tube-like features of the scaffold allow for growth of neurons, blood vessels, trachea, and other bodily parts. The patent has 2 independent claims. The first covers general features of the...
Implantable artificial organ and physiological monitoring system
Patent Number: 6750055This patent covers an implantable culture system that uses islet cells and/or stem cells for treatment of diabetes. What is interesting about this patent is that it actually involves a mechanism of detecting insulin so that the culture system and other additions to the body can be perform in order to maintain homeostatic insulin concentrations. This patent is useful for small biotechs...
Injection molding of living tissues
Patent Number: 6773713This patent teaches how to combine computer engineering design tools together with stem cell technologies for the formation of 3 dimensional tissues that may subsequently be implanted.
Tissue matrices comprising placental stem cells, and methods of making the same
Patent Number: 7,311,904The use of decellularized tissue as a scaffold onto which stem cells may be seeded has previously been patented. In the current patent the unique approach is taken that embryonic-like stem cells, as described in patent 7,311,905 are utilized to seed the...
Methods of generating tissue using devitalized, acellular scaffold matrices derived from micro-organs
Patent Number: 7,297,540In the area of stem cell biology many say that "microenvironment is everything". In the current patent, the inventors take this literally. They developed a method of taking tissue, decellularizing it, and using it as a scaffold for new stem cells to grow on. The invention covers such an approach for the generation of "mini-organs" or "micro-organs" including, small subsets of skin, lung...
Process for ex vivo formation of mammalian bone and uses thereof
Patent Number: 6811776This patent teaches how to use bone stem cells, or bone precursor cells in order to generate in vitro bones that can be subsequently introduced in vivo. The invention is of use to any biotech interested in entering the regenerative market in the area of osteogenesis.
Implantable biodegradable devices for musculoskeletal repair or regeneration
Patent Number: 7,192,604The current patent covers methods of producing biodegradable scaffolds for implantation of stem cells, committed progenitors, or differentiated cells into a host primarily for the purposes of healing or regenerating musculoskeletal tissue. Covered is an implantable device made of fibers with varying degrees of biodegradability designed so that scaffold degradation is coordinated with...