Class: 3D Culture/Scaffold (88)
Connective tissue substitutes, method of preparation and uses thereof
Patent Number: 7,335,230One of the areas in which regenerative medicine has caused the most advancement is in repair of connective tissue injuries. The current patent addresses this area. Specifically, the patent covers an object that can be implanted and used as a substitute for a connective tissue. The objected is made with a pair of bone anchors, with at least one filament connecting the bone achors at their...
Methods for fabricating a filament for use in tissue engineering
Patent Number: 6730252This patent covers generation of filaments that are useful for forming three dimensional scaffolds for tissue engineering using stem cells or precursor cells.
Tissue engineered biografts for repair of damaged myocardium
Patent Number: 7,214,371This patent covers various matrices that are seeded with cells in vitro and implanted in vivo into myocardial tissue so as to allow regeneration or healing. The patent uses a porous polysaccharide composition for shaping the matrics since it allows optimal cell viability and differentiation in vitro. The patent also covers embedding of various growth factors and cytokines in the matrix so...
Scaffolds for tissue engineered hair
Patent Number: 7,198,641This patent covers scaffolds that are useful for hair replacement. Essentially the patent has claims around a scaffold that is made of: - a bioabsorbable polymer - hair follicle progenitor cells The scaffold having the shape approximately to the shape of a hair follicle. The assignee company, Aderans Research Institute, Inc., is extensively involved in both making wigs, as well as...
Patterned substrates and methods for nerve regeneration
Patent Number: 6676675This patent provides biocompatible surfaces which can be used for growing nerve cells on that are derived from stem cells. This type of technology will be critical for generation of neural networks in vitro and in vivo, and eventually for the ability to expand central nervous system function.
Process for producing a vascularized bioartificial tissue and an experimental reactor for carrying out the process
Patent Number: 6960427At face value this patent seems to be extremely broad. The issued claims, which have one independent claim, cover pretty much any type of vascularized bioengineered tissue. The claim is not restricted to type of tissue or method of generating the tissue. It covers the introduction of at least one blood vessel into either a tissue or a matrix which has cells in it, growing of the tissue in...
Process for ex vivo formation of mammalian bone and uses thereof
Patent Number: 7,229,826This patent covers a method of identifying genes associated with generation of bone tissue. The one issued claim covers the growth of a bone progenitor cell in media containing one or more members of the TGF family, and then assessing gene expression modification as the bone progenitor cells are differentiating into bone.
Device having a microporous membrane lined deformable wall for implanting cell cultures
Patent Number: 6479066This patent covers an implantable 3 dimensional matrix that takes the shape of the cavity it is administered in. This matrix is a great delivery system for introduction of various cell types into the host. In some ways this patent is useful for generation of compositions useful for the treatment of bone defects, livers, and other bodily structures.
Bioprosthetic heart valves
Patent Number: 6660260This patent coves a heart valve that secretes nitric oxide. This patent is useful for treatment of various diseases associated with valvular dysfunction such as aortic insufficiency and mitral stenosis. The roles of nitric oxide in the cardiovascular system range from vasodilation, to inhibition of apoptosis.
Porous tissue scaffoldings for the repair or regeneration of tissue
Patent Number: 6534084The importance of scaffolds in tissue engineering can not be understated. In this patent, various composition of matter, included foam-based and biodegradable scaffolds are provided.