Class: Differentiation (182)
Ligands that modulate differentiation of mesenchymal stem cells
Patent Number: 6022540This patent covers the induction of mesenchymal stem cell differentiation by activation of a ligand called ALCAM. Mesenchymal stem cells can differentiate into a wide variety of non-hematopoietic tissues and are useful for many clinical applications since they can be transplanted across allogeneic barriers, therefore knowing how to modulate their differentiation...
Vertebrate embryonic patterning-inducing proteins, compositions and uses related therto
Patent Number: 7,144,997This patent covers the use of hedgehog proteins and various analogues for maintaining neuron and neuronal stem cell viability. The claims cover specific compositions of matter, whereas the specification teaches various means of using the compositions of matter for protecting dopaminergic neurons from cell death.
The basis of this patent is described in another
Cysteine variants of erythropoietin
Patent Number: 7,314,921This patent covers the composition of matter for specific variants of erythropoietin, the renal secreted hormone responsible for generation of erythrocyte differentiation from bone marrow hematopoietic stem cells. Specifically, the patent covers variants of the erythropoietin molecule in which the amino acid cysteine is substituted for amino acids that are not essential for erythropoietin...
Directed maturation of CD34 negative stem cells to programmable antigen presenting cells
Patent Number: 6586243This patent teaches ways of generating dendritic cells from human hematopoietic stem cells and furthermore teaches how to pulse these dendritic cells with tumor antigens for use as cancer vaccines. This approach is similar in some ways to work performed by Eli Gilboa and the company Argos Therapeutics.
Electrospraying apparatus and method for introducing material into cells
Patent Number: 6093557This patent teaches methods of introducing materials into cells. It is useful for introducing genes into cells to cause differentiation, or alternatively introducing cytoplasm of embryonic stem cells into adult cells in order to "rejuvenate" them.
Keratinocyte culture from precursor cells
Patent Number: 5968546This patent provides compositions for treatment of skin defects, including burn wounds, through culture and diffentiation of keratinocyte stem cells, and subsequent administration of the keratinocyte stem cells in vivo.
Differentiation of human embryonic germ cells
Patent Number: 6562619This patent teaches the utilization of ligands that activate gp130 for the induction of differentiation of embryonic germ stem cells.
Formation of human bone in vivo using ceramic powder and human marrow stromal fibroblasts
Patent Number: 5914121This patent teaches how to use bone marrow stromal cells (are they similar to mesenchymal stem cells??) for generation of artificial bone. The use of various matrices, including ceramic powder is disclosed for practicing this invention.
Directed maturation of stem cells and production of programmable antigen presenting dentritic cells therefrom
Patent Number: 6251665This patent covers the use of hematopoietic stem cells to generate dendritic cells. The dendritic cells disclosed are able to elicit an antitumor immune response.
Programmable antigen presenting cell of CD34 lineage
Patent Number: 6228640Disclosed in this patent are methods of generating antigen-loaded dendritic cells useful for cancer immunotherapy, through the differentiation of hematopoietic stem cells.