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Patents (1329 Stem Cell Patents)

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Class: Differentiation (178)

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Neurogenic differentiation (neurod) genes

Patent Number: 5695995

This patent teaches specific gene sequences that transcribe proteins which induce differentiation of stem cells into neurons.

Inventors: Weintraub, deceased, Harold M. (late of Seattle, WA); Lee, Jacqueline E. (Denver, CO); Hollenberg, Stanley M. (Portland, OR); Tapscott, Stephen J. (Seattle, WA)

Assignee: Fred Hutchinson Cancer Research Center (Seattle, WA)

Date of First Priority Issue: Friday May 6th, 1994

Stimulating the differentiation of preadipocytic cells and therapies based thereon

Patent Number: 6248791

This patent covers ways of inducing the differentiation of cells into adipocytes that are responsive to insulin. This is for the treatment of type II diabetes.

Inventors: Ailhaud, Gerard (Nice, FR); Grimaldi, Paul (Nice, FR); Safonova, Irina (Nice, FR); Shroot, Braham (Antibes, FR); Reichert, Uwe (Pont du Loup, FR)

Assignee: Centre International de Recherches Dermatologiques Galderma (Valbonne, FR)

Date of First Priority Issue: Saturday April 2nd, 1994

Methods and kits for stimulating production of megakaryocytes and thrombocytes

Patent Number: 6051415

C reactive protein is produced by the liver in times of inflammation. This patent discloses various mutants of CRP that are capable of stimulating production of increased platelets. Given that TPO, another agent that stimulates platelet production, can stimulate self renewal of primitive hematopoietic stem cells, it would be interesting to...

Inventor: Potempa, Lawrence A. (Deerfield, IL)

Assignee: Immtech International, Inc. (Evanston, IL)

Date of First Priority Issue: Wednesday February 23rd, 1994

Methods and kits for stimulating production of megakaryocytes and thrombocytes

Patent Number: 5939529

This patent covers the use of various types of C Reactive Protein mutants for the stimulation of platelet production. CRP is actually made naturally by the liver in times of inflammation. I wonder if natural CRP also has hematopoietic effects?

Inventor: Potempa, Lawrence A. (Deerfield, IL)

Assignee: Immtech International Inc. (Evanston, IL)

Date of First Priority Issue: Wednesday February 23rd, 1994

Polynucleotides encoding haemopoietic maturation factor

Patent Number: 5922572

This patent covers peptide sequences from the "hematopoietic maturation factor", a protein that stimulates differentiation of hematopoietic stem cells.

Inventors: Rosen, Craig A. (Laytonsville, MD); Olsen, Henrik (Gaithersburg, MD); Adams, Mark D. (North Potomac, MD); Kirkness, Ewen (Washington, DC)

Assignee: Human Genome Sciences, Inc. (Rockville, MD)

Date of First Priority Issue: Tuesday January 25th, 1994

Method of promoting chondrocyte differentiation with hedgehog related polypeptides

Patent Number: 6610656

This patent teaches the use of hedgehog proteins for inducing stem cells to differentiate into the chondocytic lineage (useful for repairing of cartilage).

Inventors: Ingham, Philip W. (Summertown, GB); McMahon, Andrew P. (Lexington, MA); Tabin, Clifford J. (Cambridge, MA)

Assignee: President and Fellows of Harvard College (Cambridge, MA) Imperial Cancer Research Technology, Ltd. (London, GB)

Date of First Priority Issue: Thursday December 30th, 1993

Vertebrate embryonic pattern-inducing proteins and uses related thereto

Patent Number: 6607913

This is a composition of matter patent on molecules associated with embryonic differentiation of the hedgehog family. These molecules can provide a wealth of possibilities in regenerative medicine, especially given that they have receptors in numerous types of embryonic stem cells.

Inventors: Ingham, Philip W. (Summertown, Oxford OX27L, GB); McMahon, Andrew P. (Lexington, MA); Tabin, Clifford J. (Cambridge, MA)

Assignee: None Stated

Date of First Priority Issue: Thursday December 30th, 1993

Vertebrate embryonic pattern-inducing proteins, and uses related thereto

Patent Number: 5844079

This patent covers hedgehog proteins and their derivatives. These compositions of matter are very important for embryonic development and can be used for the expansion and differentiation of a wide variety of stem cells.

Inventors: Ingham, Philip W. (Summertown, GB2); McMahon, Andrew P. (Lexington, MA); Tabin, Clifford J. (Cambridge, MA)

Assignee: President and Fellows of Harvard College (Cambridge, MA)

Date of First Priority Issue: Thursday December 30th, 1993

Method of inducing and maintaining neuronal cells

Patent Number: 6686198

This patent teachs how to induce neural differentiation of stem cells through activation of the activin receptor associated pathways. One wonders if this patent is also applicable to bone marrow stem cells, or bone marrow stem cells induced to dedifferentiated by epigenetic modification.

Inventors: Melton, Douglas A. (Lexington, MA); Hemmati-Brivanlou, Ali (New York, NY)

Assignee: President and Fellows of Harvard College (Cambridge, MA)

Date of First Priority Issue: Thursday October 14th, 1993

Methods for differentiating neural stem cells to glial cells using neuregulins

Patent Number: 6033906

This patent covers ways of generating glial cells in vitro for in vivo use. Several growth factors and culture conditions are provided.

Inventor: Anderson, David J. (Altadena, CA)

Assignee: California Institute of Technology (Pasadena, CA)

Date of First Priority Issue: Monday July 26th, 1993

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