Class: Differentiation (177)
Method for production of neuroblasts
Patent Number: 6020197This patent covers the induction of differentiation of neural stem cells into various committed neuronal lineages. The patent provides FGF-2 for expansion of neural cells and stem cells, as well it provides various oncogenes which may be used for their immortalization.
Method for production of neuroblasts
Patent Number: 5766948This patent teaches how to generate a type of multipotential neural stem cell. These stem cells are extracted from embryonic sources. This patent may be useful for the treatment of a variety of neurodegenerative diseases.
Method of inducing cellular differentiations and altering cell phenotype using ceramide analogs
Patent Number: 5369030Ceramides are generated from membrane components by the enzyme sphingomyelinase. The importance of ceramides in cell biology is noted by their pro-apoptotic activity in certain cells, as well as ability to induce differentiation. This patent teaches that certain ceramides may be used to guide differentiation of stem cells into various lineages. It may be possible the through taking the...
Methods for differentiating neural stem cells to neurons or smooth muscle cells using TGT-.beta. super family growth factors
Patent Number: 6001654This patent teaches how to induce the differentiation of neural stem cells into either neurons or smooth muscle cells by treatment with proteins that belong to the transforming growth factor beta superfamily.
In-vitro-derived human neutrophil precursor cells
Patent Number: 5955357This patent covers the differentiation of hematopoietic stem cells into neutrophil stem cells. The neutrophil stem cell is a type of cell that gives rise primarily to neutrophils upon further differentiation.
Method for the preparation of in vitro-derived human neutrophil precursor cells
Patent Number: 5700691This patent teaches how to differentiate hematopoietic stem cells into a type of stem cell that is committed to the neutrophil lineage. These "committed" stem cells may be administered into a neutropenic patient until endogenous neutrophils rebound.
Methods and compositions for obtaining mature dendritic cells
Patent Number: 7,198,948Dendritic cells are the most potent antigen presenting cell of the immune system. Essentially, they "tell" T cells what to attack and what not to attack. The first inventor of the current patent, Ralph Steinman is considered the discoverer of the dendritic cells. The patent covers a method of making dendritic cells from stem cells. According to the claims, the method involves...
Megakaryocyte potentiator
Patent Number: 5498698This patent discloses a protein that stimulates production of platelets. This protein may be similar to thrombopoietin and should be investigated further.
Morphogen-induced periodontal tissue regeneration
Patent Number: 5733878This patent provides various morphogens, such as OP-1 for the regeneration of various dendal components, including tooth sockets.
Ketamine analogues for treatment of thrombocytopenia
Patent Number: 5384331Ketamine is used as an anasthetic in veterinary medicine, as well as for some human uses. This patent teaches various chemical modifications of ketamine that stimulate production of stem cells that are committed to generating platelets. The importance of stimulating platelet production is seen by the number of companies working on either thrombopoietin analogues or antibodies to the...