Class: Differentiation (178)
Ketamine analogues for treatment of thrombocytopenia
Patent Number: 5384331Ketamine is used as an anasthetic in veterinary medicine, as well as for some human uses. This patent teaches various chemical modifications of ketamine that stimulate production of stem cells that are committed to generating platelets. The importance of stimulating platelet production is seen by the number of companies working on either thrombopoietin analogues or antibodies to the...
In vitro induction of dopaminergic cells
Patent Number: 5981165This patent teaches how to generate in vitro neurons that produce dopamine. The neurons are generated from stem cells through culture in FGF and TGF beta family members, as well as in the presence of feeder cell layers.
Methods and uses of connective tissue growth factor for differentiation of mesenchymal stem cells
Patent Number: 6464983This patent teaches how to induce mesenchymal stem cells into chondrocytes (to make cartilage) or osteoblasts (to make bone) through the use of the cytokine called Connective Tissue Growth Factor. This patent is useful for regenerative purposes in the area of injuries, however it is interesting in that the mesenchymal stem cell patents are owned by Osiris and should be licensed in order to...
Protein-induced morphogenesis in liver tissue
Patent Number: 6531445This patent teaches the use of proteins such as osteogenic protein-1 (OP-1) for stimulation of liver regeneration.
Morphogen-induced liver regeneration
Patent Number: 5849686This patent provides various morphogens that can be administered in vivo for the induction of liver regeneration. This patent is useful alone, or in combination with exogenous stem cell delivery for treatment of hepatic disorders. This patent is especially interesting in light of recent work using cord blood stem cells for liver regeneration.
Method for enhancing the implantation and differentiation of marrow-derived mesenchymal cells
Patent Number: 5197985Mesenchymal stem cells are a topic of intense investigation and subject to several clinical trials, including by Osiris Therapeutics who are currently in Phase III for treatment of graft versus host disease. This is one of the older patents on mesenchymal stem cells that teaches the differentiation of mesenchymal stem cells into bone forming cells. This is...
Maturation of hemopoietic cells
Patent Number: 5246699This patent teaches a really interesting way of stimulating myelopoiesis by exposing myeloid precursor cells to a compound called IgE binding factor. Myeloid precursors are important for generation of neutrophils and therefore protecting from opportunistic diseases. Stimulation of myeloid cells by this approach may be useful for immune modulation as well, some papers suggest that myeloid...
Method for regulating neuron development and maintenance
Patent Number: 6177402This patent teaches how to induce differentiation of neurons, as well as to enhance their survival using a variety of growth factors, including leukemia inhibitory factor.
Use of neutral soluble glucan preparations to stimulate platelet production
Patent Number: 5488040beta.(1-3) glucan is used clinically as an immune stimulator. This patent teaches that beta glucan can be used to stimulate production of platelets by acting at the level of the hematopoietic stem cell. Beta glucan's mechanism of doing this appears to be currently unknown. Given the wide availablity and safety profile of beta glucan, this patent is useful for clinical development if...
Methods for regulating the specific lineages of cells produced in a human hematopoietic cell culture, methods for assaying the effect of substances on lineage-specific cell production, and cell compositions produced by these cultures
Patent Number: 6667034This patent covers ways of ex vivo stimulation of bone marrow and other hematopoietic cells so that after transplantation they may engraft faster. Some of the methods thought in the patent include ways of stimulating production of specific blood cell lineages that may be more important for the specific condition being treated by hematopoietic stem cell transplantation.