Class: Differentiation (176)
Method of producing a polypeptide having human granulocyte colony stimulating factor activity
Patent Number: 5994518This patent covers ways of generating a molecule that has granulocyte colony stimulating activity. It may be that this molecule is similar to G-CSF which is currently sold as "Neupogen" by the company Amgen.
Potentiation of erythropoiesis
Patent Number: 5032507This patent covers the discover that follicle stimulating hormone releasing protein (FRP) can potentiate the activity of erythropoitin in terms of induce erythropoiesis. The patent covers this concept from three perspectives in its three independent claims. The first perspective is "a method for determining the erythrodifferentiation-potentiating capacity of hematopoietic stem...
Polypeptide capable of differentiating and maturing malignant cells into normal cells or capable of accelerating the formulation of erythroblasts
Patent Number: 5847078Disclosed is a novel peptide that is useful for terminally differentiating leukemic cells. This peptide could be generally used for luekemia therapy, but should also be considered in combination with some other differentiation inducing agents such as retinoic acid.
Analogs of pluripotent granulocyte colony-stimulating factor
Patent Number: 6004548This patent covers hematopoietic stem cell stimulatory peptides and proteins that are analogs of pluripotent G-CSF. These compounds are useful for stimulation of hematopoiesis after ablation with radiotherapy or chemotherapy.
Inducing granulocyte production or B cell production in peripheral blood by TGF-.beta.
Patent Number: 5529982TGF-beta is a cytokine with numerous anti-inflammatory functions. The importance of TGF-beta at controlling inflammation is seen not only in its ability to prevent autoimmunity in several animal models, but also by the fact that tumor cells secrete large quantities of it in order to escape immune-mediated killing. This patent teaches...
Method for producing substance capable of stimulating differentiation and proliferation of human granulopoietic stem cells
Patent Number: 4342828This patent teaches how to make a hematopoietic-stimulatory substance through taking out blood, extracting monocytes and macrophages, culturing them with a glycoprotein from urine, and collecting/concentrating the resulting composition, which is useful for stimulating the proliferation and differentiation of human granulopoietic stem cells. This may be an interesting way to generate growth...