Class: Differentiation (176)
Modulation of cell fates and activities by phthalazinediones
Patent Number: 7,326,690This patent covers a pharmaceutical agent, and numerous derivatives thereof, for manipulation of cellular and stem cell activity. The family of compounds covered are called phthalazinediones, and they have previously been described to possess various anti-inflammatory activities. The patent claims include methods of treatment for metabolic diseases and methods of decreasing metabolic...
Modulation of cell fates and activities by diketo phthalazines
Patent Number: 6953799This patent teaches ways of modulating "stress" in cells through administration of "therapeutically effective amount of a phthalazine dione" in its one independent claim. The Assignee company, Bach Pharma, Inc is currently practicing the patent in the form of a registered drug (in Russia), Galavit® whose chemically active substance is Monosodium 5-Amino...
Bone marrow cell differentiation
Patent Number: 7,169,608The patent describes a simple method of inducing differentiation of bone marrow into islets by a simple two step culture approach involving an initial culture in low concentration of glucose (at least 3 days) followed by a subsequent culture in high concentration of glucose (at least 7 days). The resulting cells generate insulin in response to sugar, and are capable of preventing...
Compositions and methods for inducing osteogenesis
Patent Number: 7,273,864This is a composition of matter patent on a series of compounds capable of inducing generation of bone tissue by inducing maturation of bone precursor cells and/or inducing transdifferentiation. The examples section shows that treating mesenchymal stem cells in vitro with the compounds induces formation of osteocytes, as well as synergy with certain members of the bone morphogenic protein...
Oligodendrocytes derived from human embryonic stem cells for remyelination and treatment of spinal cord injury
Patent Number: 7,285,415The central nervous system is comprised of neurons and glia, with approximately ten times more glial cells than neurons. The function of glial cells is primarly to provide insulation(ie generation of myelin by oligodendrocytes), destroy pathogens/clear debris (microglia), provide structural support to neurons, as well as providing nutrients and growth factors. Astrocytes are the most...
Generating vascular smooth muscle cells in vitro from ES cells
Patent Number: 7,354,763This patent covers the generation of vascular smooth muscle cells from embryonic stem cells through specific culture conditions. In one embodiment the differentiation is induced through exposure to the cytokines TGF, angiopoietin, and platelet derived growth factor BB.
In the examples section the generation of SMA positive cells from embryonic stem cells is demonstrated, as...
Method for generating primate trophoblasts
Patent Number: 7,148,062It is known that embryonic stem cells can be differentiated into a wide variety of tissues in vitro. In this patent, methods are disclosed for generating trophoblasts from ES cells through culture in BMP2, BMP4, BMP7, and GDF5. Although the patent teaches uses of the trophoblasts generated for research purposes, a very interesting...
Method for differentiating rat hepatic stem cells to insulin-producing cells
Patent Number: 7029915The invention teaches how to make liver stem cells into cells that resemble pancreatic endocrine cells (ie islets). The patent has 1 independent claim, basically covering a method of endowing hepatic stem cells with an endocrine pancreatic characteristic by first isolating hepatic stem cells from 2-acetylamino-fluorene-treated adult rats and then growing the cells in a medium made of >5.5...
Methods for identifying compounds which modulate hematopoiesis
Patent Number: 7,250,262This patent covers the monitoring of numerous genes as a marker of hematopoietic stem cells proliferation, differentiation, and/or induction into apoptosis. This patent is useful for screening of compounds for potential hematopoietic modulatory activity, as well as in vivo assessment of drugs. Particularly, in clinical trials it is better if some of these "biomarkers" can be prognostic of...
Endoderm cells from human embryonic stem cells
Patent Number: 7,326,572This is one of Geron's numerous patents covering not only composition of matter for various stem cells (licensed from WARF) but also methods of actually differentiating the cells into different other cells that are useful either potentially for therapy or for research use. The current patent covers generation of endoderm through culturing of ES cells with Activin...