Class: Differentiation (179)
Primitive neural stem cells and method for differentiation of stem cells to neural cells
Patent Number: 7,211,434Generation of neurons and neuronal committed cells from embryonic stem cells has been extensively documented by separation of cells from embryoid bodies. However the generation of embryoid bodies from embryonic stem cells is subject to US patent #"6602711":http://www.stemcellpatents.com/patents-show-373 which is owned by WARF and licensed to Geron. So while the whole...
Substituted 5-alkynyl pyrimidines having neurotrophic activity
Patent Number: 7,205,297This patent discloses a series of companies that are substituted 5-alkynyl pyrimidines with nerve growth factor-like (NGF) activity for treatment of neurological disorders.
Essentially, the data the inventors disclosed in the patent is that these compounds they generated can induce promotion of neurite outgrowth and elevation of choline acetyltransferase in the PC12... This patent teaches that transfection of neuronal stem cells with dlx induces their differentiation into neurons that express GABA. This is useful for generation of cell therapies of neurodegenerative diseases. This patent discloses chondrocytes and suitable biocompatible polymers that may be administered in vivo for the regeneration, or de novo generation of cartilage tissue. This patent covers ways of generating human neural stem cells, or committed stem cells, from embryonic stem cells. The patent has 2 independent claims.
The first teaches culturing of the embryonic stem cells with an agent that inhibits a bone morphogenic protein "default pathway" so that the differentiated cell that is produced loses at least one marker of the embryonic stem cell. This... This patent teaches how to make astrocytes into neurons and/or oligodendrocytes. The ability to perform this in large scale would allow for cell replacement therapy for a variety of neural degenerative conditions. The independent claims are:
An in vitro method to produce a population that includes neurons and/or oligodendrocytes, the method comprising: (a) obtaining and/or isolating a... When people wonder why Geron's valuation is so high (half a billion) even though they are far from the clinic...well the answer is strong IP such as the current patent.
This patent blocks anyone from differentiating neurons from embryonic stem cells and using them to screen compounds for:
1. toxicity
2. viability in culture
3. induction of alterations in neurotransmitter... This patent covers synthetic oligonucleotides (composition of matter) derived from promoter of gamma globulin, which stimulate erthrocytic differentiation.
The patent is useful for treatment of patients post chemotherapy increase hemoglobin counts, and also for development of in vitro erythrocyte culture systems. The mechanism by which these oligonucleotides work appears unclear. This patent covers methods of differentiating embryonic stem cells into hepatocytes. Hepatocytes are very attractive since they can be used as a single cell therapy for restoring cirrhotic livers.
The patent covers the use of the differentiation agents:sodium butyrate, n-butyric acid, trichosratin A, propionic acid, isobutyric acid, and isovaleric acid for generating hepatocytes.
The... Medical advances of embryonic stem cells may indeed come initially from their use as research reagents before actually being developed as therapeutics. For example, few member of the public realize that practically all molecular biology was made possible by the mouse embryonic stem cell, which allowed for development of knockout and transgenic mice.
In the current patent Geron covers...
Production of gabaergic cells
Patent Number: 6602680
Method of generating cartilage
Patent Number: 6719970
Methods of culturing embryonic stem cells and controlled differentiation
Patent Number: 7,112,437
Transdifferentiation of glial cells
Patent Number: 6897061
Screening small molecule drugs using neural cells differentiated from human embryonic stem cells
Patent Number: 7,250,294
Synthetic oligonucleotides as inducers of erythroid differentiation
Patent Number: 7,262,175
Process for making hepatocytes from pluripotent stem cells
Patent Number: 7,256,042
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Hepatocytes for therapy and drug screening made from embryonic stem cells
Patent Number: 7,282,366
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