Class: Differentiation (177)
Platform for the differentiation of cells
Patent Number: 6638765This patent covers methods of dedifferentiating cells, and redifferentiating them in order to produce islet-like cells for the treatment of diabetes.
Transdiffentiation of transfected epidermal basal cells into neural progenitor cells, neuronal cells and/or glial cells
Patent Number: 7041507This invention teaches how to generate neurons from skin. Essentially, the inventors found that through the process of isolating epidermal stem cells (basal cells), transfected said basal cells with genes encoding neurogenic transcription factors, suppressing transcription factors that maintain a differentiated phenotype (by for example antisense), and then culturing the cells with exogenous...
Transdifferentiation of epidermal basal cells into neural progenitor cells, neuronal cells and/or glial cells
Patent Number: 6949380This invention is similar to patent 7041507, which was filed by the same inventors. The current invention teaches generation of neuronal-like cells through the transdifferentiation of epidermal basal cells. The invention has 3 independent claims covering, "An in vitro method of transdifferentiating an epidermal basal cell ", "A kit for transdifferentiating, in vitro, an epidermal...
Conversion of non-neuronal cells into neurons: transdifferentiation of epidermal cells
Patent Number: 6087168This patent teaches how to induce "trandifferentiation" of epidermal cells into neurons. The neurons are useful for treatment of neurodegenerative diseases.
Method of genetically modifying very primitive quiescent human hematopoietic stem cells
Patent Number: 6919209Gene therapy is limited by ability to transfect quiescent cells. Since the very primitive hematopoietic stem cells reside in a quiescent state, it is difficult to transfect them. This patent demonstrates transfection of early hematopoietic stem cells using an adeno-associated vector. The patent has one independent claim that covers:
A method for stably transferring
Low intensity light therapy for the manipulation of fibroblast, and fibroblast-derived mammalian cells and collagen
Patent Number: 6676655This patent provides frequencies of light that effect extracellular and cellular components. This patent is useful for regulation of stem cells after implantation into a host through non-pharmacological means.
Alginate layer system for chondrogenic differentiation of human mesenchymal stem cells
Patent Number: 6761887Mesenchymal stem cells can be used as "universal donors" since they do not elicit rejection in certain situations. This patent teaches methods of differentiating mesenchymal stem cells into cartilage through growth on alginate layers.
Lymphoid tissue-specific cell production from hematopoietic progenitor cells in three-dimensional devices
Patent Number: 6548299This patent teaches how to generate cells of the lymphoid lineage in vitro through a variety of devices and culture techniques. This patent could be used for generating T suppressor cells in order to antigen-specifically inhibit autoimmunity.
Hematopoietic differentiation of human pluripotent embryonic stem cells
Patent Number: 6280718This patent covers ways of inducing the generation of hematopoietic stem cells from embryonic stem cells. This is very useful since it may be possible to generate allogeneic hematopoietic stem cells for the whole population using such a method.
Method for producing dendritic cells
Patent Number: 7,247,480Dendritic cells are one of the most important cells of the immune system, having the unique ability to stimulate naive T cells. Additionally, under specific conditions, dendritic cells can give rise to T regulatory cells and dampen immune responses. The current patent teaches ways of generating dendritic cells from embryonic stem cells by culturing embryoid bodies with IL-3 and/or...