Class: Use (227)
Methods for assisting recovery of damaged brain and spinal cord using arrays of X-ray microplanar beams
Patent Number: 7,158,607One of the problems with cell therapy after injury is the possibility of accelerating scar tissue formation. The current patent teaches the use of X-rays, administered by parallel micro-beams at doseages that are sufficient to remove inhibitors of regeneration. The patent also discloses the use of exogenous stem cells in combination with the X-rays in order to accelerate healing.
Methods for assisting recovery of damaged brain and spinal cord using arrays of X-Ray microplanar beams
Patent Number: 7,305,064It has always been the belief of StemCellPatents.com that the future of stem cell therapeutics is not only in the development and use of stem cell types, but the integration of stem cells with other modalities to attain synergy. For example, while FDA/EMEA development of cellular product candidates takes years and hundreds of millions of dollars, the same, or very...
Compositions, systems and methods for treatment of defects in blood vessels
Patent Number: 7,201,918Vascular aneurysms are thinning of blood vessel walls, which is usually associated with vessel trauma, non-specific degeneration, atherosclerosis, or infection. The term "aneurysm" comes from the Latin "aneurysma" which means "dilation". Aneurysms are hazardous because of the potential to burst. They are usually prevelant in the aorta or cerebral arteries. The current patent provides...
Genome mutation by intron insertion into an embryonic stem cell genome
Patent Number: 7,205,148Genetic manipulation of ES cells provides a powerful method for developing unique cell line models of various human diseases. More clinically applicable is the possibility of specifically producing mutations in genes that elicit rejection of ES cells, so as to generate "universal donor" stem cells. This patent teaches ways of generating mutations in exons of genes in ES cells by...
Myocardial stimulation
Patent Number: 7,349,740The positive effects of stem cells in cardiac conditions is supported by many clinical trials. Efficacy has been demonstrated by both intracoronary administration, as well as intravenous administration of bone marrow and mesenchymal stem cells, respectively.
In this patent, Medronics was granted some pretty far-reaching claims. This is a representative claim
"A...
Methods and compositions to treat myocardial conditions
Patent Number: 7,294,334Myocardial infarctions cause massive lose of cardiac muscle, as well as cause numerous electrophysiological dysfunctions that can immediately or in the long-term lead to death. The current patent has 2 independent claims that deal with this. The first one teaches the application of a pacing therapy in the infarct area together with the percutaneous administration of porcine "donor...
Therapeutic cellular stent
Patent Number: 7044965This patent covers a type of stent that contains cells and is useful not only for maintaining open a blood vessel, but also for delivery of cells that secrete various agents useful for the body. The patent has two independent claims, the first covering a stent containing cells, the second covering a method of administering cells into an organism. Stents have been covered with many agents in...
Cardiac stimulation system with delivery of conductive agent
Patent Number: 7,317,950This patent covers a device that stimulates conductivity of electrical signals in the heart. Amongst the uses of the invention is to ensure proper biventricular septal pacing. The invention claims the use of various cells, including stem cells, for increasing certain conductivity connections.
Keratinocytes useful for the treatment of wounds
Patent Number: 7,306,943Although the patent describes a keratinocyte population, the fact that the cells claimed can proliferate past the Hayflick limit, stimulated us to discuss this patent. The use of allogeneic cells for covering burns and other types of wounds has been widely known in the art, however in the current patent a type of keratinocyte with immense proliferative potential is described. The patent...
Quantitative RT-PCR to AC133 to diagnose cancer and monitor angiogenic activity in a cell sample
Patent Number: 7,252,976Based on the title, one would think that this patent covers global use of PCR amplifying for CD133 transcripts in order to detect angiogenic propensity in a host. If this were the case, then the patent indeed would be very strong.
The patent, however, is restricted to covering the diagnosis of colorectal cancer using PCR...