Patents (1436 Stem Cell Patents)

Class: Extraction/Preservation (156)

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Monoclonal antibodies to mesenchymal stem cells

Patent Number: 7,476,540

This patent covers antibodies that bind to mesenchymal stem cells.  The antibodies are deposited as hybridomas under accession numbers KCLRF-BP-000123, KCLRF-BP-000124 or KCLRF-BP-000125 at the Korean Cell Line Research Foundation (Cancer Research Institute, Seoul National University, College of Medicine, 28 Yongondong, Chongno-Gu, Seoul, 110-744, Korea).  The antigen appears to be...

Inventors: Song; Yeong-Wook (Seoul, KR), Yoo; Hyun-Jung (Busan, KR), Yoon; Sung-Soo (Seoul, KR), Park; Seonyang (Seoul, KR), Park; Weon-Seo (Goyang-si, KR), Kim; Dong-Jo (Seoul, KR), Lee; Eun-Bong (Seoul, KR)
Assignee: Seoul National University Industry Foundation (Seoul, KR)
Date of First Priority Issue: Tuesday January 10th, 2006

Cord blood and placenta collection kit

Patent Number: 7,147,626

Celgene, through its wholly owned subsiduary Anthrogenesis (now called Celgene Cellular Therapeutics) has been active in the cord blood IP area, through patents covering innovative methods of extracting stem cells from the placental matrix itself . In the current patent, Celgene covers a kit for collecting not only the umbilical...

Inventors: Goodman; Chris B. (Green Brook, NJ), Robinson; Wayne Malcolm (Hampton, NJ), Feingold; Barnett Dov (New York, NY)
Assignee: Celgene Corporation (Summit, NJ)
Date of First Priority Issue: Thursday September 23rd, 2004 5 Comments

Methods for identifying stem cells based on nuclear morphotypes

Patent Number: 7,427,502

Stem cells are usually identified based on markers such as CD34 for hematopoietic stem cells, or CD133 for cancer stem cells, or specific properties such as expression of aldehyde dehydrogenase.  Interestingly, in this patent the morphological characteristics of the stem cell are covered...

Inventors: Gostjeva; Elena V. (Winchester, MA), Thilly; William G. (Winchester, MA)
Assignee: Massachusetts Institute of Technology (Cambridge, MA)
Date of First Priority Issue: Thursday June 17th, 2004

Preparation of a cell concentrate from a physiological solution

Patent Number: 7,291,450

The use of bone marrow mononuclear cells as a source of stem cells has been widely described in numerous medical procedures ranging from stimulation of angiogenesis in patients with peripheral artery disease to treatment of terminal liver failure, to treatment of heart disease. Unfortunately the use of...

Inventors: Sowemimo-Coker; Samuel O. (Dix Hills, NY), Scott; Marcus Lee (Memphis, TN), Long; Marc (Memphis, TN), Margerrison; Ed (Germantown, TN), Cooper; Michael B. (Memphis, TN)
Assignee: Smith & Nephew, Inc. (Memphis, TN); Pall Corporation (East Hills, NY)
Date of First Priority Issue: Wednesday December 10th, 2003

Anti-CD33 antibodies and method for treatment of acute myeloid leukemia using the same

Patent Number: 7,342,110

One of the major technological advances that allowed for the characterization and use of stem cells was the development of defined monoclonal antibodies that repeatedly attached to markers on stem cells. For example, the patents covering the original hematopoietic stem cells used monoclonal antibodies to actually identify the cell...

Inventors: Hoffee; Mary G. (Brookline, MA), Tavares; Daniel (Natick, MA), Lutz; Robert J. (Wayland, MA)
Assignee: Immunogen Inc. (Cambridge, MA)
Date of First Priority Issue: Wednesday November 5th, 2003

Stem cell-specific promoters and their use

Patent Number: 7,396,680

The current patent covers the nucleic acid sequences for promoters.  In the claims it just states "promoters" but the specification teaches that the promoters are specific to "stem cells".  The examples part of the patent teaches that they are active in CD34 and CD133 cells found from cord blood.

Being able to have patents on actual promoter sequences that...

Inventors: Shmelkov; Sergey V. (New York, NY), Rafii; Shahin (Great Neck, NY), Lin; Jun (Forest Hills, NY)
Assignee: Cornell Research Foundation, Inc. (Ithaca, NY)
Date of First Priority Issue: Friday October 31st, 2003

Methods of identifying and isolating stem cells and cancer stem cells

Patent Number: 7,217,568

This patent teaches that tumor stem cells can be extracted population of non-stem cells by selecting for the cells which have activation of the transcription factor LEF/TCF and/or the beta.-catenin pathway. This patent essentially takes a pathway that is known to be activated in non-malignant sttem cells and simply applies it to malignant stem cells. Some may...

Inventors: Jamieson; Catriona Helen M. (Palo Alto, CA), Ailles; Laurie Elizabeth (Stanford, CA), Reya; Tannishtha (Mountain View, CA), Weissman; Irving L. (Redwood City, CA)
Assignee: The Board of Trustees of the Leland Stanford Junior University (Palo Alto, CA)
Date of First Priority Issue: Friday May 30th, 2003

Two-stage culture protocol for isolating mesenchymal stem cells from amniotic fluid

Patent Number: 7101710

This patent useful for parties looking for methodologies to purify mesenchymal stem cells from amniotic fluid. The patent has 3 independent claims. Essentially all three are directed towards a two step culture process where amniotic fluid cells are first grown in a vessel, subsequently non-adherent cells are isolated, and allowed to expand. The difference between the claims is the media used...

Inventors: Tsai, Ming-Song (Taipei, TW); Hwang, Shiaw-min (Hsinchu 300, TW)
Assignee: Unknown Assignee(s)
Date of First Priority Issue: Wednesday February 12th, 2003

Progenitor cells from wharton's jelly of human umbilical cord

Patent Number: 7,547,546

This patent covers methods of extracting an adherent mesenchymal-like stem cells from the Wharton's Jelly of the umbilical cord.  The extracted cells are negative for MHC and are termed by the inventors human umbilical cord perivascular (HUCPV) cells.  In the examples section the the cells are demonstrated to be capable of differentiating into osteocytes, chondrocytes, adipocytes, and...

Inventors: Davies; John E. (Toronto, CA), Baksh; Dolores (Mississauga, CA), Sarugaser; Rahul (Toronto, CA), Hosseini; Morris (Braunschweig, DE), Lickorish; Antony D. S. (Toronto, CA)
Assignee: Tissue Regeneration Therapeutics Inc. (Toronto, Ontario, CA)
Date of First Priority Issue: Tuesday February 11th, 2003

Bone marrow aspiration system

Patent Number: 6981948

As mentioned in our discussion about patent # 7008394, bone marrow harvesting is a relatively invasive procedure. This is also very relavant for regenerative uses of bone marrow where patients with a heart attack or stroke are harvested. Accordingly there is a need to develop less invasive and increasingly sterile means of harvesting. The current patent has two independent claims covering...

Inventors: Pellegrino, Richard C. (Mendon, MA); Voellmicke, John C. (Cumberland, RI)
Assignee: DePuy Spine, Inc. (Raynham, MA)
Date of First Priority Issue: Monday November 18th, 2002

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