Class: Extraction/Preservation (146)
Cord blood and placenta collection kit
Patent Number: 7,147,626Celgene, through its wholly owned subsiduary Anthrogenesis (now called Celgene Cellular Therapeutics) has been active in the cord blood IP area, through patents covering innovative methods of extracting stem cells from the placental matrix itself . In the current patent, Celgene covers a kit for collecting not only the...
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Preparation of a cell concentrate from a physiological solution
Patent Number: 7,291,450The use of bone marrow mononuclear cells as a source of stem cells has been widely described in numerous medical procedures ranging from stimulation of angiogenesis in patients with peripheral artery disease to treatment of terminal liver failure, to treatment of
Anti-CD33 antibodies and method for treatment of acute myeloid leukemia using the same
Patent Number: 7,342,110One of the major technological advances that allowed for the characterization and use of stem cells was the development of defined monoclonal antibodies that repeatedly attached to markers on stem cells. For example, the patents covering the original hematopoietic stem cells used monoclonal antibodies to actually identify the...
Methods of identifying and isolating stem cells and cancer stem cells
Patent Number: 7,217,568This patent teaches that tumor stem cells can be extracted population of non-stem cells by selecting for the cells which have activation of the transcription factor LEF/TCF and/or the beta.-catenin pathway. This patent essentially takes a pathway that is known to be activated in non-malignant sttem cells and simply applies it to malignant stem cells. Some may...
Two-stage culture protocol for isolating mesenchymal stem cells from amniotic fluid
Patent Number: 7101710This patent useful for parties looking for methodologies to purify mesenchymal stem cells from amniotic fluid. The patent has 3 independent claims. Essentially all three are directed towards a two step culture process where amniotic fluid cells are first grown in a vessel, subsequently non-adherent cells are isolated, and allowed to expand. The difference between the claims is the media used...
Bone marrow aspiration system
Patent Number: 6981948As mentioned in our discussion about patent # 7008394, bone marrow harvesting is a relatively invasive procedure. This is also very relavant for regenerative uses of bone marrow where patients with a heart attack or stroke are harvested. Accordingly there is a need to develop less invasive and increasingly sterile means of harvesting. The current patent has two independent claims covering...
Buffy coat tube and float system and method
Patent Number: 7,329,534This patent covers a device that is capable of separating various cellular populations, or populations of particulate matter. Essentially, the device addresses the need for an easy to use, effective, and rapid method of collecting the "buffy coat" from a blood population, as well as cells within the buffy coat. The device purifies the cells using axial expansion of blood fluid components...
Antibodies isolating and/or identifying neuronal stem cells and method for isolating and/or identifying neuronal progenitor cells
Patent Number: 7,182,946Methods of purifying stem cells, as well as progenitor cell populations are well known in the art. Unfortunately, some of these methods have certain limitations, and as a result, there is always a great need to identify new ways of sometimes doing the same thing. For example, it is known that CD34 is a useful marker for hematopoietic stem cells. However, since the...
CD56 positive human adult pancreatic endocrine progenitor cells
Patent Number: 7,371,576The quest for a stem cell therapy for diabetes has led to the evaluation of numerous cellular sources ranging from embryonic stem cells, to bone marrow derived stem cells, to mesenchymal stem cells. One interesting method of expanding insulin producing cells is through extraction of pancreatic...
Method and apparatus for sorting biological cells with a MEMS device
Patent Number: 6838056This patent covers a medical device that is useful for purifying hematopoietic stem cells. The medical device selects stem cells but not contaminating cancer cells, and is therefore useful for treatment of cancer patients by purifying autologous stem cells before high dose chemotherapy so that the stem cells can be re-introduced in order to accelerate reconstitution of hematopoiesis.