Patents (1436 Stem Cell Patents)

Class: 3D Culture/Scaffold (92)

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Compositions and methods for promoting attachment of cells of endothelial cell lineage to medical devices

Patent Number: 7,531,505

Lack of proper endothelialization of vascular grafts can cause a variety of problems such as restenosis or thrombosis.  The current patent covers a coating for medical devices in which one side of the coating binds to the metallic surface of the device and the other side contains peptides that bind to endothelium or endothelial precursor cells. ...

Inventors: Hamilton; Paul Theodore (Cary, NC), Kenan; Daniel James (Chapel Hill, NC), Solan; Amy Katherine (Durham, NC)
Assignee: Affinergy, Inc. (Durham, NC)
Date of First Priority Issue: Wednesday January 11th, 2006

Three dimensional bioengineered smooth muscle tissue and sphincters and methods therefor

Patent Number: 7,368,279

This patent covers methods of producing artificial sphincters.  Specifically, smooth muscle cells are grown on an extracellular matrix that is placed on a tissue culture vessal coated with polydimethyl siloxane and a mold made of a cylindrical shape which is coated with the same material.  Examples of extracellular matrices useful for the invention include fibrin.  The patent...

Inventors: Bitar; Khalil N. (Ann Arbor, MI), Hecker; Louise (Ann Arbor, MI), Baar; Keith (Dundee, GB), Somara; Sita (Ypsilanti, MI)
Assignee: The Regents of The University of Michigan (Ann Arbor, MI)
Date of First Priority Issue: Wednesday November 24th, 2004

Musculo-skeletal implant having a bioactive gradient

Patent Number: 7,351,423

It is known that stem cells migrate towards injured tissue in response to chemotactic gradients.  For example the basal SDF-1 gradient made by bone marrow stromal cells is why it is possible to achieve hematopoietic reconstitution by injecting donor cells intravenously.  Similarly, SDF-1 acts as a gradient to call stem cells into damaged myocardium after a...

Assignee: Depuy Spine, Inc. (Raynham, MA)
Date of First Priority Issue: Wednesday September 1st, 2004

Modified hyaluronic acid for use in musculoskeletal tissue repair

Patent Number: 7091191

This patent is useful for making scaffolds onto which stem cells, progenitor cells, or other type of cells can be seeded, and the scaffold together with the seeded cells are implanted in vivo. Previous scaffold technologies using hyaluronic acid have the drawback of very rapid resorption in the body, not giving the cells enough time to integrate and function properly. This patent uses a novel...

Inventors: Laredo, Walter R. (Hillsborough, NJ); Rezania, Alireza (Hillsborough, NJ)
Assignee: Ethicon, Inc. (Somerville, NJ)
Date of First Priority Issue: Friday December 19th, 2003 1 Comment

Conformable tissue repair implant capable of injection delivery

Patent Number: 7,316,822

This patent covers an implantable matrix that includes: a) the matrix itself; b) live cells; and c) tissue fragments. The matrix itself is made of granules which are resorbable and bear a specific size. The tissue fragments include cartilage, meniscus, tendon, ligament, dermis, bone, fat, and combinations thereof. The overall mixture may be injected for treatment of a variety of degenerative...

Inventors: Binette; Francois (Weymouth, MA), Hammer; Joseph J. (Bridgewater, NJ), Mukhopadhyay; Krish (Bridgewater, NJ), Rosenblatt; Joel (Watchung, NJ)
Assignee: Ethicon, Inc. (Somerville, NJ)
Date of First Priority Issue: Sunday November 23rd, 2003

Methods for treating dental conditions using tissue scaffolds

Patent Number: 7,309,232

This patent covers a method of forming new dentin (the calcified tissue of the body of the tooth, underneath the enamel) in teeth through administration of a tissue scaffold which stem cells can grow on and regenerate the dentin. Some of the stem cells covered include stem cells from the dental pulp. Indeed it is quite interesting...

Inventors: Rutherford; Bruce (Seattle, WA), Somogyi; Christopher (Woodinville, WA), White; Clinton (Raleigh, NC), Rabins; Erick (Seattle, WA)
Assignee: Dentigenix Inc. (Seattle, WA)
Date of First Priority Issue: Friday October 10th, 2003

In vivo synthesis of connective tissues

Patent Number: 7,375,077

The current invention teaches the generation of connective tissue in vivo.  Specifically, stem cells that have been differentiated into connective tissue cells, such as fibroblasts, are placed in a scaffold, with two other scaffolds surrounding the scaffold containing the cells.  The two other scaffolds on the top and the bottom of the middle scaffold contain growth factors and...

Inventors: Mao; Jeremy Jian (Chicago, IL)
Assignee: The Board of Trustees of the University of Illinois (San Diego, CA)
Date of First Priority Issue: Friday September 19th, 2003

Acellular matrix implants for treatment of articular cartilage, bone or osteochondral defects and injuries and method for use thereof

Patent Number: 7,217,294

This patent covers a method of inducing articular cartilage healing/regeneration through the implantation of acellular matrices that can be used for either delivery of cells or growth factors. The patent is written as one independent claim covering essentially: a)the scaffold; b) a sealant that protects the scaffold from debris; c) the implantation of the scaffold; and d) the deposition of...

Inventors: Kusanagi; Akihiko (Brookline, MA), Tarrant; Laurence J. B. (Northampton, MA), Schmidt; Mary Beth (Pomfret Center, CT)
Assignee: Histogenics Corp. (Northampton, MA)
Date of First Priority Issue: Wednesday August 20th, 2003

Decellularized bone marrow extracellular matrix

Patent Number: 7,326,571

Numerous patents have been filed on de-cellularized tissues for use as matrices. For example, patent # 6,696,074 teaches that various fetal tissues may be de-cellularized and used as scaffolds. Such scaffolds may be seeded with various differentiated or stem cells, such as Inventors: Freyman; Toby (Watertown, MA)

Assignee: Boston Scientific Scimed, Inc. (Maple Grove, MN)
Date of First Priority Issue: Thursday July 17th, 2003

Aligned scaffolds for improved myocardial regeneration

Patent Number: 7,384,786

Stem cell therapy for cardiac indications may take a variety of forms.  One of the easiest is intravenous administration of mesenchymal stem cells after a myocardial infarction.  This would require the stem cells to selectively home into damaged tissue.  It is known that various inflammatory agents such as IL-18 and...

Inventors: Freyman; Toby (Waltham, MA), Palasis; Maria (Wellesley, MA), Ungs; Mark (Minnetonka, MN)
Assignee: Scimed Life Systems, Inc. (Maple Grove, MN)
Date of First Priority Issue: Wednesday July 16th, 2003

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