Class: 3D Culture/Scaffold (92)

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Compositions and methods for promoting attachment of cells of endothelial cell lineage to medical devices

Patent Number: 7,531,505

Lack of proper endothelialization of vascular grafts can cause a variety of problems such as restenosis or thrombosis.  The current patent covers a coating for medical devices in which one side of the coating binds to the metallic surface of the device and the other side contains peptides that bind to endothelium or endothelial precursor cells. ...

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Three dimensional bioengineered smooth muscle tissue and sphincters and methods therefor

Patent Number: 7,368,279

This patent covers methods of producing artificial sphincters.  Specifically, smooth muscle cells are grown on an extracellular matrix that is placed on a tissue culture vessal coated with polydimethyl siloxane and a mold made of a cylindrical shape which is coated with the same material.  Examples of extracellular matrices useful for the invention include fibrin.  The patent...

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Musculo-skeletal implant having a bioactive gradient

Patent Number: 7,351,423

It is known that stem cells migrate towards injured tissue in response to chemotactic gradients.  For example the basal SDF-1 gradient made by bone marrow stromal cells is why it is possible to achieve hematopoietic reconstitution by injecting donor cells intravenously.  Similarly, SDF-1 acts as a gradient to call stem cells into damaged myocardium after a...

Assignee: Depuy Spine, Inc. (Raynham, MA)

Date of First Priority Issue: Wednesday September 1st, 2004

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Modified hyaluronic acid for use in musculoskeletal tissue repair

Patent Number: 7091191

This patent is useful for making scaffolds onto which stem cells, progenitor cells, or other type of cells can be seeded, and the scaffold together with the seeded cells are implanted in vivo. Previous scaffold technologies using hyaluronic acid have the drawback of very rapid resorption in the body, not giving the cells enough time to integrate and function properly. This patent uses a novel...

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Conformable tissue repair implant capable of injection delivery

Patent Number: 7,316,822

This patent covers an implantable matrix that includes: a) the matrix itself; b) live cells; and c) tissue fragments. The matrix itself is made of granules which are resorbable and bear a specific size. The tissue fragments include cartilage, meniscus, tendon, ligament, dermis, bone, fat, and combinations thereof. The overall mixture may be injected for treatment of a variety of degenerative...

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Methods for treating dental conditions using tissue scaffolds

Patent Number: 7,309,232

This patent covers a method of forming new dentin (the calcified tissue of the body of the tooth, underneath the enamel) in teeth through administration of a tissue scaffold which stem cells can grow on and regenerate the dentin. Some of the stem cells covered include stem cells from the dental pulp. Indeed it is quite interesting...

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In vivo synthesis of connective tissues

Patent Number: 7,375,077

The current invention teaches the generation of connective tissue in vivo.  Specifically, stem cells that have been differentiated into connective tissue cells, such as fibroblasts, are placed in a scaffold, with two other scaffolds surrounding the scaffold containing the cells.  The two other scaffolds on the top and the bottom of the middle scaffold contain growth factors and...

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Acellular matrix implants for treatment of articular cartilage, bone or osteochondral defects and injuries and method for use thereof

Patent Number: 7,217,294

This patent covers a method of inducing articular cartilage healing/regeneration through the implantation of acellular matrices that can be used for either delivery of cells or growth factors. The patent is written as one independent claim covering essentially: a)the scaffold; b) a sealant that protects the scaffold from debris; c) the implantation of the scaffold; and d) the deposition of...

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Decellularized bone marrow extracellular matrix

Patent Number: 7,326,571

Numerous patents have been filed on de-cellularized tissues for use as matrices. For example, patent # 6,696,074 teaches that various fetal tissues may be de-cellularized and used as scaffolds. Such scaffolds may be seeded with various differentiated or stem cells, such as Inventors: Freyman; Toby (Watertown, MA)

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