Class: Differentiation (190)
Methods of producing pancreatic hormones
Patent Number: 7,534,608The company Novocell (merged from Cythera, BresaGen, and Novocell) has been strategically developing an IP portfolio covering numerous aspects of treating diabetes.
Having IP on endoderm, as well as encapsulation technologies, the company recently was issued the current patent covering generation of insulin producing cells from embryonic stem...
Method of generating human retinal progenitors from embryonic stem cells
Patent Number: 7,541,186This patent covers the generation of retinal progenitor cells from embryonic stem cells. Neural stem cells have previously been demonstrated to have ability to differentiate into retinal tissue, as well as embryonic stem cell derived cells.
The current patent covers a methodology involving the generation of...
Direct differentiation method for making cardiomyocytes from human embryonic stem cells
Patent Number: 7,452,718One of the important areas of research in embryonic stem cells involves design of novel ways to upscale production of differentiated cells. Another important area is developing cells that may be used clinically. The company Novocell, for example, has developed various systems of expanding embryonic stem cells without the use of mouse feeder... Continuing its tradition of IP excellence, Novocell took a very interesting angle in the current patent. Covered are tests for identifying factors that can induce stem cell differentiation into endoderm. The first independent claim is: " A method of identifying a factor that promotes the differentiation of human definitive endoderm cells, said method comprising... This patent covers methods of generating cells with a neuronal phenotype from cells that possess the activin receptor. Specifically, the invention provides the finding that ectodermal tissue can be induced to differentiate into neuronal tissues by inhibiting signaling of the activin receptor.
This patent has very broad reaching consequences since conceptually it covers activin receptor... This patent discloses a novel peptide that is capable of inducing osteoblast proliferation and induction of bone synthesis. The peptide disclosed may be used as part of an implantable composition of cells and biodegradable matrices for the treatment of bone fractures.
The patent covers numerous methods of making the peptide, as well as chemical derivatives and methods of... This patent covers a method of culturing cells, including stem cells by providing flow conditions simular to what may be found in an in vivo system. The invention aims to meet the following goals: (1) supplying a substance uniformly to the cells to be cultured; (2) establishing a uniform flow for supplying a substance; (3) eliminating a dead space; and (4) preventing release of cell... The current patent teaches methods of inducing differentiation of various adult stem cells into neuronal-like cells through culture on a blood clot alone or in the presence of various other cells and/or growth factors. It is known that various components released during the blood clotting process are mitogenic to stem cells, compoenents such as PDGF and
Methods for identifying factors for differentiating definitive endoderm
Patent Number: 7,541,185
Method of inducing and maintaining neuronal cells
Patent Number: 7,264,968
Peptide with osteogenic activity
Patent Number: 7,163,920
Device and method for culturing cells
Patent Number: 7,358,082
Methods of producing neurons
Patent Number: 7,186,557
Methods of regulating differentiation in stem cells
Patent Number: 7,413,903This patent covers the use of agonists of LPL receptors to inhibit differentiation of embryonic stem cells.
The inhibition of embryonic stem cell differentiation is important since the innate tendency of these cells is to differentiate when grown in absence of specific feeder cells and cytokines. While companies such as Geron have patents on specific culture systems that...
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Osteogenesis-promotion enhancer and method of screening the same
Patent Number: 7,276,525This patent covers 2 main concepts. The first is acceleration of osteogenesis through administration of a bone morphogenic protein together with an inhibitor of TGF-beta. The claims also go on to cover a specific chemical entitiy that inhibits TGF-beta. The second main part of the patent is claim 3 in which the screening of compounds that...