Class: Differentiation (175)
Method of inducing and maintaining neuronal cells
Patent Number: 7,264,968This patent covers methods of generating cells with a neuronal phenotype from cells that possess the activin receptor. Specifically, the invention provides the finding that ectodermal tissue can be induced to differentiate into neuronal tissues by inhibiting signaling of the activin receptor. This patent has very broad reaching consequences since conceptually it covers activin receptor...
Peptide with osteogenic activity
Patent Number: 7,163,920This patent discloses a novel peptide that is capable of inducing osteoblast proliferation and induction of bone synthesis. The peptide disclosed may be used as part of an implantable composition of cells and biodegradable matrices for the treatment of bone fractures. The patent covers numerous methods of making the peptide, as well as chemical derivatives and methods of...
Device and method for culturing cells
Patent Number: 7,358,082This patent covers a method of culturing cells, including stem cells by providing flow conditions simular to what may be found in an in vivo system. The invention aims to meet the following goals: (1) supplying a substance uniformly to the cells to be cultured; (2) establishing a uniform flow for supplying a substance; (3) eliminating a dead space; and (4) preventing release of cell...
Methods of producing neurons
Patent Number: 7,186,557The current patent teaches methods of inducing differentiation of various adult stem cells into neuronal-like cells through culture on a blood clot alone or in the presence of various other cells and/or growth factors. It is known that various components released during the blood clotting process are mitogenic to stem cells, compoenents such as PDGF and
Osteogenesis-promotion enhancer and method of screening the same
Patent Number: 7,276,525This patent covers 2 main concepts. The first is acceleration of osteogenesis through administration of a bone morphogenic protein together with an inhibitor of TGF-beta. The claims also go on to cover a specific chemical entitiy that inhibits TGF-beta. The second main part of the patent is claim 3 in which the screening of compounds that...
Methods for inducing differentiation of pluripotent cells
Patent Number: 7,332,336Mesenchymal stem cells are originally thought of as bone marrow derived, adherent cells, that have the ability to differentiate into a variety of tissues. Initial studies demonstrated that mesenchymal stem cells can differentiate into bone, cartilage, fat and muscle. These cells possess a very strong possibility for commercialization and therapeutics development since they can be administered...
Promoting cardiac cell differentiation
Patent Number: 7,271,254This patent covers the composition of matter for the myofibrillogenesis-inducing RNA (MIR) molecule. MIR appears to be important for myofibrillogenesis (a stage in cardiogenesis) in a type of salamander called the Mexican axolotl. Since the claims cover composition of matter for a molecule found on a non-human species, it will be...
Marker system for preparing and characterizing high-quality human embryonic stem cells
Patent Number: 7,153,650This patent covers the use of the gastrin related peptide receptor (GRP receptor) as a marker of embryonic stem cell differentiation. Essentially when embryonic stem cells differentiate they start to downregulate expression of GRP receptor. This assay is useful for knowing the state of differentiation of embryonic stem cells. Since Geron is anticipating to enter...
Protein-induced morphogenesis of kidney tissue
Patent Number: 7,196,056This patent has three main areas covered in its claims:
1. Induction of new kidney tissue growth.
2. Induction of kidney morphogenesis.
3. Repair of kidney tissue.
These are performed by administration of appropriate concentrations of the following proteins: OP-1, OP-2, BMP-2, BMP-4, BMP-5,
Method of generating neurons from stem cells and medium for culturing stem cells
Patent Number: 7,252,995This patent covers the use of medium obtained from the supernatant of cultured hippocampal neurons for use in the induction of neural differentiation of stem cells. The stem cells that can be differentiated into neurons by culture in the media include: - Embryonic stem cells - Embryonic germ cells - Embryonic carcinoma - Bone marrow stromal cells - Bone marrow hematopoietic...
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