Patents (1436 Stem Cell Patents)

Class: Differentiation (190)

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Methods of producing pancreatic hormones

Patent Number: 7,534,608

The company Novocell (merged from Cythera, BresaGen, and Novocell) has been strategically developing an IP portfolio covering numerous aspects of treating diabetes. 

Having IP on endoderm, as well as encapsulation technologies, the company recently was issued the current patent covering generation of insulin producing cells from embryonic stem...

Inventors: Martinson; Laura (San Diego, CA), Kroon; Evert (San Diego, CA), D'Amour; Kevin (San Diego, CA), Baetge; Emmanuel Edward (Encinitas, CA)
Assignee: Cythera, Inc. (San Diego, CA)
Date of First Priority Issue: Friday March 2nd, 2007

Method of generating human retinal progenitors from embryonic stem cells

Patent Number: 7,541,186

This patent covers the generation of retinal progenitor cells from embryonic stem cells.  Neural stem cells have previously been demonstrated to have ability to differentiate into retinal tissue, as well as embryonic stem cell derived cells. 

The current patent covers a methodology involving the generation of...

Inventors: Reh; Thomas (Seattle, WA), Lamba; Deepak (Seattle, WA)
Assignee: University of Washington (Seattle, WA)
Date of First Priority Issue: Wednesday February 22nd, 2006

Direct differentiation method for making cardiomyocytes from human embryonic stem cells

Patent Number: 7,452,718

One of the important areas of research in embryonic stem cells involves design of novel ways to upscale production of differentiated cells.  Another important area is developing cells that may be used clinically.  The company Novocell, for example, has developed various systems of expanding embryonic stem cells without the use of mouse feeder...

Assignee: Geron Corporation (Menlo Park, CA)
Date of First Priority Issue: Friday March 26th, 2004

Methods for identifying factors for differentiating definitive endoderm

Patent Number: 7,541,185

Continuing its tradition of IP excellence, Novocell took a very interesting angle in the current patent. 

Covered are tests for identifying factors that can induce stem cell differentiation into endoderm.

The first independent claim is:

" A method of identifying a factor that promotes the differentiation of human definitive endoderm cells, said method comprising...

Inventors: D'Amour; Kevin Allen (San Diego, CA), Agulnick; Alan D. (San Marcos, CA), Eliazer; Susan (San Diego, CA), Baetge; Emmanuel E. (Encinitas, CA)
Assignee: Cythera, Inc. (San Diego, CA)
Date of First Priority Issue: Tuesday December 23rd, 2003

Method of inducing and maintaining neuronal cells

Patent Number: 7,264,968

This patent covers methods of generating cells with a neuronal phenotype from cells that possess the activin receptor. Specifically, the invention provides the finding that ectodermal tissue can be induced to differentiate into neuronal tissues by inhibiting signaling of the activin receptor. This patent has very broad reaching consequences since conceptually it covers activin receptor...

Inventors: Melton; Douglas A. (Lexington, MA), Hemmati-Brivanlou; Ali (New York, NY)
Assignee: President and Fellows of Harvard College (Cambridge, MA)
Date of First Priority Issue: Tuesday October 14th, 2003

Peptide with osteogenic activity

Patent Number: 7,163,920

This patent discloses a novel peptide that is capable of inducing osteoblast proliferation and induction of bone synthesis. The peptide disclosed may be used as part of an implantable composition of cells and biodegradable matrices for the treatment of bone fractures. The patent covers numerous methods of making the peptide, as well as chemical derivatives and methods of...

Inventors: Dhanaraj; Sridevi (Raritan, NJ), Gosiewska; Anna (Skillman, NJ), Rezania; Ali (Hillsborough, NJ), Heavner; George A. (Malvern, PA), Lin; Xuanhan (Bridgewater, NJ), Yi; Chin-Feng (Hillsborough, NJ)
Assignee: Ethicon, Inc. (Somerville, NJ)
Date of First Priority Issue: Tuesday September 30th, 2003

Device and method for culturing cells

Patent Number: 7,358,082

This patent covers a method of culturing cells, including stem cells by providing flow conditions simular to what may be found in an in vivo system.  The invention aims to meet the following goals: (1) supplying a substance uniformly to the cells to be cultured; (2) establishing a uniform flow for supplying a substance; (3) eliminating a dead space; and (4) preventing release of cell...

Inventors: Tsuzuki; Hirohiko (Kanagawa, JP), Toda; Satoru (Kanagawa, JP), Ichikawa; Yasunori (Kanagawa, JP), Kurahashi; Tetsuo (Kanagawa, JP), Shiraishi; Fumiko (Kanagawa, JP)
Assignee: FUJIFILM Corporation (Tokyo, JP)
Date of First Priority Issue: Wednesday July 16th, 2003

Methods of producing neurons

Patent Number: 7,186,557

The current patent teaches methods of inducing differentiation of various adult stem cells into neuronal-like cells through culture on a blood clot alone or in the presence of various other cells and/or growth factors. It is known that various components released during the blood clotting process are mitogenic to stem cells, compoenents such as PDGF and Inventors: Marko; Olga (Houston, TX)

Assignee: Isolagen Technologies, Inc. (Houston, TX)
Date of First Priority Issue: Friday June 13th, 2003

Methods of regulating differentiation in stem cells

Patent Number: 7,413,903

This patent covers the use of agonists of LPL receptors to inhibit differentiation of embryonic stem cells. 

The inhibition of embryonic stem cell differentiation is important since the innate tendency of these cells is to differentiate when grown in absence of specific feeder cells and cytokines.  While companies such as Geron have patents on specific culture systems that...

Inventors: Pebay; Alice Marie (Melbourne, AU), Pera; Martin Frederick (Prahran, AU)
Assignee: ES Cell International PTE Ltd. (Victoria, AU)
Date of First Priority Issue: Friday June 6th, 2003 2 Comments

Osteogenesis-promotion enhancer and method of screening the same

Patent Number: 7,276,525

This patent covers 2 main concepts. The first is acceleration of osteogenesis through administration of a bone morphogenic protein together with an inhibitor of TGF-beta. The claims also go on to cover a specific chemical entitiy that inhibits TGF-beta. The second main part of the patent is claim 3 in which the screening of compounds that...

Inventors: Miyazono; Kohei (Shiki, JP), Imamura; Takeshi (Tokyo, JP), Maeda; Shingo (Tokyo, JP)
Assignee: Nippon Shinyaku Co. Ltd. (Kyoto, JP)
Date of First Priority Issue: Thursday June 5th, 2003

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