Patents
Culture system for rapid expansion of human embryonic stem cells
Patent Number: 7,410,798This patent covers methods of expanding embryonic stem cells in vitro in large quantities without inducing their differentiation. Essentially the method covered is represented by the first independent claim which discloses the culture system which contains an extracellular matrix, a non-conditioned medium, and 40 nanograms per ml of FGF. The claim also states that the culture is...
Method of preparing an undifferentiated cell
Patent Number: 7,410,773This patent is either way ahead of its time, or there are some problems in its commercialization. The patent covers a method of "dedifferentiating" mature cells in order to an immature phenotype or to increase the ability of the cells to act like stem cells.
The first claim of the patent covers a means of augmenting the number of cells expressing a stem cell...
Meningeal-derived stem cells
Patent Number: 7,410,797The current patent covers a type of multipotent stem cell derived from the meninges. This is the three layered membrane that surrounds the cerebrospinal fluid and central nervous system. The inventors have demonstrated that cells isolated from this membrane, regardless of whether they are from the dura mater, pia mater, or arachnoid mater, can be substantially expanded in vitro...
Kits for treatment of hematologic disorders
Patent Number: 7,408,039Hematopoietic stem cell transplantation has saved many lives of patients with hematological and metabolic malignancies. Unfortunately, one of the major side effects of this treatment is graft versus host. The company Osiris is in advanced stages of clinical trials (Phase III) using mesenchymal stem cells to treat this condition in which lymphocytes from the donor start attacking the...
Methods for introducing heterologous cells into fish to determine if the heterologous cells contain cancer cells or a pathogen
Patent Number: 7,408,095In general it is quickly forgotten that the biggest contribution of embryonic stem cell technology to medicine has not been in the area of actually generating therapeutics, but in development of model systems for studying diseases. It was only through the generation of knockout and transgenic animals that we as biologists were able to start deciphering the in vivo relevance of the...
Cosmetic compositions
Patent Number: 7,405,195The current patent covers a cosmetic generated using a variant of stromal derived factor (SDF-1) which the inventors termed stem cell active factor (SCAF). The natural function of SDF-1 is to call in stem cells to injured tissue, for example, after a heart attack there is a surge of SDF-1 which is involved in mediating mobilization of stem cells from the bone... Plasticity of stem cells to differentiate into various tissues is often a subject of much debate, especially in terms of bone marrow hematopoietic stem cells becoming hepatocytes or cardiac cells. While some scientists state that a hematopoietic stem cell will only differentiate into blood cells, others point to the clinical evidence that administration of, for example bone marrow... Hepatic fibrosis is associated with overproduction of collagen by stellate cells, as well as killing of hepatocytes by these cells. In some situations stem cells have demonstrated positive effects in clinical liver failure, both bone marrow stem cells, as well as mobilized peripheral blood stem cells. One mechanism... Pregnancy associated plasma protein-A (PAPP-A) is a protease that cleaves insulin-like growth factor binding-protein (IGFBP-4). PAPP-A is used experimentally as a diagnostic for myocardial infarction and also is indicative of various congenital abnormalities in utero. Interestingly, if PAPP-A is knocked out or functionally inactivated in mice, there is reduced levels of IGF activity... This is a patent with priority in 1999 describing the use of genetically modified Sertoli cells for immune protection of implanted cells AND the use of the Sertoli cells themselves as the vector...genetic engineer with any gene is covered. This patent is part of the Canadian company Sernova's (CDNX:SVA.V) potent intellectual property... 
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Generation and use of dendritic cells
Patent Number: 7,405,076
Treatment of disease by inducing cell apoptosis
Patent Number: 7,402,567
Longevity and PAPP-A
Patent Number: 7,402,724
Production of a biological factor and creation of an immunologically privileged environment using genetically altered Sertoli cells
Patent Number: 7,399,751