Patents
T cell differentiation of CD34+ stem cells in cultured thymic epithelial fragments
Patent Number: 5766944Disclosed are methods of generating T cells in vitro from CD34+ hematopoietic stem cells. Specifically, the use of thymic fragments are provided so as to recapitulate in vivo thymopoiesis.
Inventor: Ruiz, Margaret Eileen (Chevy Chase, MD)
Assignee: None stated
Date of First Priority Issue: Tuesday December 31st, 1996
Methods, compositions and devices for maintaining and growing human stem and/or hematopoietics cells
Patent Number: 5763266Specific bioreactors and culture conditions are provided for the expansion of hematopoietic stem cells. These cells may be used directly for treatment post marrow ablation, or may be further differentiated into specific hematological cells for treatment of specific diseases.
Inventors: Palsson, Bernhard O. (Ann Arbor, MI); Emerson, Stephen G. (Wayne, PA); Schwartz, Richard M. (San Mateo, CA)
Assignee: The Regents of the University of Michigan (Ann Arbor, MI)
Date of First Priority Issue: Thursday March 4th, 1993
Human hematopoietic stem cell
Patent Number: 5763197This patent teaches the use of the CD34+, lineage negative hematopoietic stem cell as a target for the in vitro screening and identification of drugs. For example, libraries may be screened for ability to inhibit or stimulate proliferation, or alternatively to induce differentiation into various lineages.
Inventors: Tsukamoto, Ann (Palo Alto, CA); Baum, Charles M. (Mountain View, CA); Aihara, Yukoh (Yokohama, JP); Weissman, Irving (Palo Alto, CA)
Assignee: Systemix, Inc. (Palo Alto, CA)
Date of First Priority Issue: Friday March 30th, 1990
Human liver epithelial cell lines
Patent Number: 5759765This patent teaches the use of immortalized human hepatic epithelial cells for testing toxicity of agents in vitro. This is a rapid and easy way to test for potential toxicity of various candidates without having to perform animal testing.
Inventors: Harris, Curtis C. (Bethesda, MD); Cole, Katharine H. (Dayton, MD); Lechner, John F. (Albuquerque, NM); Reddel, Roger (St. Ives, AU)
Assignee: The United States of America as represented by the Secretary of the (Washington, DC)
Date of First Priority Issue: Wednesday December 14th, 1988
Neuronal progenitor cells and uses thereof
Patent Number: 5753505This patent provides a new type of neural stem cell that can be used for screening or therapeutic purposes.
Inventor: Luskin, Marla B. (Decatur, GA)
Assignee: Emory University (Atlanta, GA)
Date of First Priority Issue: Thursday July 6th, 1995
Use of neuro-derived fetal cell lines for transplantation therapy
Patent Number: 5753491This patent covers fetally derived neuronal stem cells, alone, and after transfection with therapeutic genes. These stem cells may be transfected in order to secrete trophic factors that would allow endogenous brain stem cells to proliferate. On the other hand, they may be transfected with anti-apoptotic genes such as Xiap. Xiap transfection would allow the cells to maintain viability.
Inventors: Major, Eugene O. (Oakton, VA); Tornatore, Carlo S. (University Park, MD); Yadid, Gal (Kfar Saba, IL)
Assignee: None stated
Date of First Priority Issue: Tuesday April 13th, 1993
Human hematopoietic stem cell
Patent Number: 5750397This is one of the composition of matter patents on hematopoietic stem cells. It covers the phenotype of CD34+ and Thy1+
Inventors: Tsukamoto, Ann (Palo Alto, CA); Baum, Charles M. (Mountain View, CA); Aihara, Yukoh (Yokohama, JP); Weissman, Irving (Palo Alto, CA)
Assignee: Systemix, Inc. (Palo Alto, CA)
Date of First Priority Issue: Friday March 30th, 1990
In vitro growth and proliferation of genetically modified multipotent neural stem cells and their progeny
Patent Number: 5750376This patent covers neural stem cells of a specific phenotype and their use for delivery of gene products into an area of need.
Inventors: Weiss, Samuel (Alberta, CA); Reynolds, Brent (Alberta, CA); Hammang, Joseph P. (Barrington, RI); Baetge, E. Edward (Barrington, RI)
Assignee: NeuroSpheres Holdings Ltd. (Calgary, CA)
Date of First Priority Issue: Monday July 8th, 1991
Methods for identifying fetal cells
Patent Number: 5750339Fetal to maternal trafficking of stem cells is a relatively undiscussed phenomena. This patent covers methods of detecting fetal cells in maternal circulation, in one embodiment through identification of cells expressing the immune suppressive molecule HLA-G
Inventor: Smith, J. Bruce (Philadelphia, PA)
Assignee: Thomas Jefferson University (Philadelphia, PA)
Date of First Priority Issue: Wednesday November 30th, 1994
Expansion of human hematopoietic progenitor cells in a liquid medium
Patent Number: 5744361This patent provide tissue culture reagents for the expansion of hematopoietic stem cells.
Inventors: Hoffman, Ronald (Palo Alto, CA); Brandt, John (Palo Alto, CA)
Assignee: None stated
Date of First Priority Issue: Tuesday April 9th, 1991