Patents
Liver reserve cells
Patent Number: 5559022Liver stem cells are very interesting to study, in part because of the very potent regenerative ability of the liver. In this patent a type of liver stem cell is claimed called the "liver reserve cell". These cells are characterized by ability to be stained by methylene blue and Azure A, adherence, multinucleation, ability to differentated, and specific density on percoll.
Hematopoietic stem cell specific gene expression
Patent Number: 5556954This patent covers the promoter for CD34. CD34 is a classical marker of stem cells, not only of the hematopoietic type but also of the hepatic type. CD34 is highly glycosylated and acts as an adhesion molecule. Mice that are knocked out for CD34 still have hematopoiesis, however the stem cells to not migrate...
Methods of culturing and modulating the growth of hair follicular stem cells
Patent Number: 5556783This patent covers methods of expanding stem cells derived from the hair follicle. One of the methods of expanding hair follicle stem cells is through growing then on 3T3 fibroblasts. Hair stem cells are somewhat similar to mesenchymal stem cells and may be useful for a wide variety of applications in addition to hair replacement.
Method for implanting encapsulated cells in a host
Patent Number: 5550050Microencapsulation allows delivery of immunologically incompatible cells to a recipient. The technology of microencapsulation has been used clinically for a variety of uses, including administration of cell therapy ranging from neurons to islets. The use of embryonic stem cells may require encapsulation so has to not only overcome the allogeneic barriers, but also to prevent growth and...
Methods and compositions of a bioartificial kidney suitable for use in vivo or ex vivo
Patent Number: 5549674This patent covers an artificial kidney system designed in a manner so as to combine hollow fiber technology with living, fresh endothelial cells. This patent does mention that in some embodiments stem cells may be used for providing the necessary cells. Various artificial kidneys have been designed and the author of this patent has actually been involved in their clinical development...
Three-dimensional bone marrow cell and tissue culture system
Patent Number: 5541107In this patent regarding bone marrow stem cell culture, Advanced Tissue Sciences continues their tour de force in three dimensional culture IP, through covering the use of three dimensional cultures for expanding bone marrow stem cells. Specifically, the patent teaches that stromal cells and a three dimensional matrix can be used for expansion of hematopoietic...
Inducing granulocyte production or B cell production in peripheral blood by TGF-.beta.
Patent Number: 5529982TGF-beta is a cytokine with numerous anti-inflammatory functions. The importance of TGF-beta at controlling inflammation is seen not only in its ability to prevent autoimmunity in several animal models, but also by the fact that tumor cells secrete large quantities of it in order to escape immune-mediated killing. This patent teaches...
Treatment of immunologic and hematologic disorders with IGFBP alone or complexed with IGF
Patent Number: 5527776This patent teaches that IGF-1 together with IGF Binding Protein-3 (IGFBP-3) can be used for stimulation of hematopoiesis and specifically upregulation of erythroid production in anemic patients. This is one example of a patent covering compounds that are traditionally seen as in the domain of endocrinologists, that are applied to...
Stroma-derived proteoglycan containing composition which promotes differentiation and maintains the self-renewal capacity of long-term bone marrow culture-initiating cells
Patent Number: 5523286This patent provides a proteoglycan matrix that can be used for growth and expansion of hematopoietic stem cells. Interestingly this patent promotes not just growth of CD34+ hematopoietic stem cells, but specifically, hematopoietic stem cells that are capable of supporting long term cultures. This patent can be used for expanding hematopoietic stem cells for...
Three-dimensional pancreatic cell and tissue culture system
Patent Number: 5516681This patent teaches the use of stromal cells to support growth, proliferation, and differentiation of islet-like pancreatic structures after addition of pancreatic acinar cells to the culture. This technology can be a great basis for the numerous other stem cell technologies currrently available for islet regeneration.