Patents
Satellite cell proliferation in adult skeletal muscle
Patent Number: 5466676This patent teaches methods of transfecting various stem cells with therapeutic or marker genes. Particularly, muscle stem cells, called satellite cells are discussed as target cells suitable for transfection.
Purification and manipulation of bone marrow and blood cells on the basis of P-glycoprotein expression
Patent Number: 5464753This patent teaches that stem cells have an active efflux mechanism similar to the way that cancer cells have an efflux mechanism that makes them drug resistant. The only question about this patent is whether it also covers stem cells that are already identified using other markers. For example, it is very likely that the stem cells, at least hematopoietic stem cells that possess the efflux...
Osteogenic growth polypeptides identified from regenerating bone marrow
Patent Number: 5461034This patent covers a composition of matter (peptide) that is derived from bone marrow, that stimulates bone formation. The peptide may be useful for healing through stimulation of endogenous stem cells, as well as through administration in combination with a stem cell source so as to accelerate bone healing.
Method for culturing hematopoietic cells
Patent Number: 5460964This patent teaches the culture of hematopoietic stem cells in a manner that the cells do not adhere to the stromal cells that provide various trophic growth factors. IL-3 and MIP-1 alpha are also covered for use in the hematopoietic stem cell culture system described herein.
Device for maintaining and growing human stem and/or hematopoietics cells
Patent Number: 5459069This patent provides tissue culture devices that can be used for expansion of hematopoietic stem cells. The tissue culture devices allow for a culture of stem cells to be performed so that the stromal cells that provide various factors to the stem cells do not come into direct contact with the stem cells.
Pluripotential embryonic stem cells and methods of making same
Patent Number: 5453357This is one of the early embryonic stem cell patents. In this one embryonic stem cells are maintained in LIF, stem cell factor, and fibroblast growth factor. It is interesting to analyze this patent in light of the WARF patents because there is some very interesting similarities to the approaches.
Apparatus and method for culturing embryonic stem cells
Patent Number: 5449620Generation of knockout animals, as well as other chimeras, involves insertion of a gene-targeted embryonic stem cell into an embryo. This patent discloses a device that can physically hold the embryo so that injection of the stem cell can be performed with increased ease and accuracy.
Three-dimensional cell and tissue culture system
Patent Number: 5443950This patent claims a three dimensional structure that can be grown in vitro using stromal cells, stem cells, and other cell types, for the generation of tissue. The structure can then be introduced in vivo either to function as an organ, or to assist the function of an existing body component.
Method for the ex vivo replication of stem cells, for the optimization of hematopoietic progenitor cell cultures, and for increasing the metabolism, GM-CSF secretion and/or IL-6 secretion of human stromal cells
Patent Number: 5437994This patent teaches methods of expanding human hematopoietic cells ex vivo using various cytokine cocktails. The patent is heavily cited by other patents and its claims appear to be far-reaching.
Method of enhancing the growth of gut epithelial cells by administration of a cytokine such as interleukin II
Patent Number: 5437863Gut epithelial cells are proliferating, well at least the stem cells that give rise to them, are in a state of constant proliferation. This is one of the reasons why after chemotherapy and/or radiation therapy, there is adverse effects associated with the GI tract. This patent teaches that proliferation of these cells can be stimulated by IL-6, IL-11, LIF, Oncostatin...