Patents
Homologous recombination for universal donor cells and chimeric mammalian hosts
Patent Number: 5413923This patent teaches how to genetically delete the MHC antigens in order to have stem cells and progeny of the stem cells that are capable of acting as universal donor cells. Although this technology is at face value very interesting, the fact that other antigens besides MHC cause rejection of tissue dampens enthusiasm for this approach...
Expansion of human hematopoietic progenitor cells in a liquid medium
Patent Number: 5409825This patent uses mast cell growth factor as an additive to tissue culture media in order to generate a liquid composition that is useful for expansion of hematopoietic stem cells. The ability of this media to expand other types of stem cells should be assessed.
Medium for long-term proliferation and development of cells
Patent Number: 5405772This patent is for a tissue culture media that is capable of expanding, as well as allowing differentiation of various cell types in vitro, including hematopoietic stem cells. The media is different than other approaches since it comprises several growth factors, as well as extracellular matrix components. Importantly the media does not use serum, this is applicable for clinical ex vivo...
Methods and compositions for the optimization of human hematopoietic progenitor cell cultures
Patent Number: 5399493The genetic engineering of hematopoietic stem cells offers the potential to cure several disease, including severe combined immunodeficiency, sickle cell anemia, beta thalessemia, etc. This patent teaches how to ex vivo genetically engineer hematopoietic stem cells through the use of retroviral vectors. This patent is highly cited by other patents.
Serum-free basal and culture medium for hematopoietic and leukemia cells
Patent Number: 5397706This patent teaches the making of a serum free media for growth hematopoietic stem cells. Such a media is useful since the addition of fetal serum and especially fetal calf serum in culture medium for cell therapy is associated with regulatory hurdles.
Ketamine analogues for treatment of thrombocytopenia
Patent Number: 5384331Ketamine is used as an anasthetic in veterinary medicine, as well as for some human uses. This patent teaches various chemical modifications of ketamine that stimulate production of stem cells that are committed to generating platelets. The importance of stimulating platelet production is seen by the number of companies working on either thrombopoietin analogues or antibodies to the...
Method of inducing cellular differentiations and altering cell phenotype using ceramide analogs
Patent Number: 5369030Ceramides are generated from membrane components by the enzyme sphingomyelinase. The importance of ceramides in cell biology is noted by their pro-apoptotic activity in certain cells, as well as ability to induce differentiation. This patent teaches that certain ceramides may be used to guide differentiation of stem cells into various lineages. It may be possible the through taking the...
Method of regenerating articular cartilage
Patent Number: 5368051This patent teaches how to use growth hormone, as well as other factors for the repair of articular cartilage. The method is useful for developing not only therapeutic kits, but also as a stepping stop for new methods of using stem cells, both endogenous and exogeneous in cartilage repair.
Enhanced maintenance of pregnancy using leukaemia inhibitory factor in embryo culturing
Patent Number: 5366888This patent is assigned to Amrad, a company whose patents have recently been used to challenge the WARF patents. The current patent involves the use of LIF in enhancing ability of implanted embryos to develop into normal offspring. The relevance of this patent to embryonic stem cells is that LIF has been used...
Polypeptide derivatives of human granulocyte colony stimulating factor
Patent Number: 5362853G-CSF is used clinically for stimulation of neutrophil production in pateints that have taken chemotherapy, radiation therapy (in some cases), as well as post bone marrow tranplant. This patent covers peptide derivatives of G-CSF that are useful for stimulation of hematopoiesis. It may be interesting to use this patent to compete with currently used G-CSF formulations.