Patents
Medium for long-term proliferation and development of cells
Patent Number: 5405772This patent is for a tissue culture media that is capable of expanding, as well as allowing differentiation of various cell types in vitro, including hematopoietic stem cells. The media is different than other approaches since it comprises several growth factors, as well as extracellular matrix components. Importantly the media does not use serum, this is applicable for clinical ex vivo...
Inventor: Ponting, Ian L. O. (Woodland Hills, CA)
Assignee: Amgen Inc. (Thousand Oaks, CA)
Date of First Priority Issue: Friday June 18th, 1993
Methods and compositions for the optimization of human hematopoietic progenitor cell cultures
Patent Number: 5399493The genetic engineering of hematopoietic stem cells offers the potential to cure several disease, including severe combined immunodeficiency, sickle cell anemia, beta thalessemia, etc. This patent teaches how to ex vivo genetically engineer hematopoietic stem cells through the use of retroviral vectors. This patent is highly cited by other patents.
Inventors: Emerson, Stephen G. (Ann Arbor, MI); Clarke, Michael F. (Ann Arbor, MI); Palsson, Bernhard O. (Ann Arbor, MI); Schwartz, Richard M. (Ann Arbor, MI)
Assignee: The Regents of the University of Michigan (Ann Arbor, MI)
Date of First Priority Issue: Thursday June 15th, 1989
Serum-free basal and culture medium for hematopoietic and leukemia cells
Patent Number: 5397706This patent teaches the making of a serum free media for growth hematopoietic stem cells. Such a media is useful since the addition of fetal serum and especially fetal calf serum in culture medium for cell therapy is associated with regulatory hurdles.
Inventors: Correa, Paulo N. (Concord, Ontario, CA); Alexrad, Arthur A. (Willowdale, Ontario, CA)
Assignee: Not Stated
Date of First Priority Issue: Wednesday November 6th, 1991
Ketamine analogues for treatment of thrombocytopenia
Patent Number: 5384331Ketamine is used as an anasthetic in veterinary medicine, as well as for some human uses. This patent teaches various chemical modifications of ketamine that stimulate production of stem cells that are committed to generating platelets. The importance of stimulating platelet production is seen by the number of companies working on either thrombopoietin analogues or antibodies to the...
Inventors: Kogan, Timothy P. (Half Moon Bay, CA); Somers, Todd C. (Montara, CA)
Assignee: Genentech, Inc. (San Francisco, CA)
Date of First Priority Issue: Thursday July 18th, 1991
Method of inducing cellular differentiations and altering cell phenotype using ceramide analogs
Patent Number: 5369030Ceramides are generated from membrane components by the enzyme sphingomyelinase. The importance of ceramides in cell biology is noted by their pro-apoptotic activity in certain cells, as well as ability to induce differentiation. This patent teaches that certain ceramides may be used to guide differentiation of stem cells into various lineages. It may be possible the through taking the concepts...
Inventors: Hannun, Yusuf A. (Chapel Hill, NC); Bielawska, Alicja (Apex, NC)
Assignee: Duke University (Durham, NC)
Date of First Priority Issue: Friday September 11th, 1992
Method of regenerating articular cartilage
Patent Number: 5368051This patent teaches how to use growth hormone, as well as other factors for the repair of articular cartilage. The method is useful for developing not only therapeutic kits, but also as a stepping stop for new methods of using stem cells, both endogenous and exogeneous in cartilage repair.
Inventors: Dunn, Allan R. (North Miami, FL); Dunn, Susan L. (North Miami, FL)
Assignee: Non Stated
Date of First Priority Issue: Wednesday June 30th, 1993
Enhanced maintenance of pregnancy using leukaemia inhibitory factor in embryo culturing
Patent Number: 5366888This patent is assigned to Amrad, a company whose patents have recently been used to challenge the WARF patents. The current patent involves the use of LIF in enhancing ability of implanted embryos to develop into normal offspring. The relevance of this patent to embryonic stem cells is that LIF has been used consistently for generation of embryonic stem cells from a variety of species. The...
Inventors: Fry, Richard C. (Altona North, AU); Parr, Ronald A. (Hoppers Crossing, AU)
Assignee: Amrad Corporation Limited (AU)
Date of First Priority Issue: Monday July 9th, 1990
Polypeptide derivatives of human granulocyte colony stimulating factor
Patent Number: 5362853G-CSF is used clinically for stimulation of neutrophil production in pateints that have taken chemotherapy, radiation therapy (in some cases), as well as post bone marrow tranplant. This patent covers peptide derivatives of G-CSF that are useful for stimulation of hematopoiesis. It may be interesting to use this patent to compete with currently used G-CSF formulations.
Inventors: Kuga, Tetsuro (Yamaguchi, JP); Miyaji, Hiromasa (Tokyo, JP); Sato, Moriyuki (Tokyo, JP); Okabe, Masami (Shizuoka, JP); Morimoto, Makoto (Shizuoka, JP); Itoh, Seiga (Kanagawa, JP); Yamasaki, Motoo (Tokyo, JP); Yokoo, Yoshiharu (Kanagawa, JP); Yamaguchi, Ka
Assignee: Kyowa Hakko Kogyo Co., Ltd. (Tokyo, JP)
Date of First Priority Issue: Tuesday December 23rd, 1986
Methods for stimulating hematopoietic progenitors using hepatocyte growth factor and lymphokines
Patent Number: 5362716This patent covers stimulation of hematopoietic stem cells by administration of hepatocyte growth factor with either IL-3 or GM-CSF. Hepatocyte growth factor has been used clinically in a variety of situations including to stimulate angiogenesis. It may be interesting, in light of the claimed pro-hematopoietic stem cell activity of hepatocyte growth factor, to try using this cytokine...
Inventors: Kmiecik, Thomas E. (Frederick, MD); Vande Woude, George F. (Berryville, VA)
Assignee: The United States of America as represented by the Department of Health (Washington, DC)
Date of First Priority Issue: Wednesday December 27th, 1989
Stimulation of stem cell growth by the bryostatins
Patent Number: 5358711Bryostatin is a drug derived from a type of symbiont bacteria. Although bryostatin has been used in clinical trials for oncology, results have not been excellent. This patent teaches that bryostatin and various derivatives thereof are useful for stimulation of hematopoietic stem cell proliferation. It will be interesting to see if bryostatin works on stimulating stem cell activity of other...
Inventors: May, W. Stratford (Baltimore, MD); Sensenbrenner, Lyle L. (Grosse Pointe Park, MI)
Assignee: Johns Hopkins University (Baltimore, MD)
Date of First Priority Issue: Monday November 23rd, 1987