Patents
Apparatus for removing fluid from an umbilical cord
Patent Number: 5171527This patent provides a medical device for rapidly extracting cord blood from an umbilical cord. This may be useful for collection of cord blood stem cells, which is a common practice in current medicine.
Method for stimulating production of bone marrow cell growth factors using dithiocarbamates
Patent Number: 5169765This patent teaches that dithiocarbamate and its analogues have the ability to stimulate bone marrow production of hematopoietic growth factors. Dithiocarbamate may be used according to the invention for stimulation of hematopoietic cells to produce growth factors, and subsequently the dithiocarbamate may be taken off the cells. While this patent seems like a really interesting method of...
Method of treating hematologic diseases and pharmaceutical composition to be used therefor
Patent Number: 5166180This patent teaches ways to increase hematopoiesis through administration of some chemical compositions. The patent has 2 independent claims that essentially cover these compositions. This seems like an interesting patent but I need to actually look up and see if these compositions have been developed or not.
In vitro propagation of embryonic stem cells
Patent Number: 5166065This patent was used to argue that the WARF patents were anticipated. The patent has two independent claims. The first covering a method of isolating embryonic stem cells, and the second covering a method of maintaining embryonic stem cells. Both independent claims use leukemia inhibitory factor to allow for the ex vivo growth of stem cells without loss of...
Method for the treatment of grafts prior to transplantation using TGF-.beta .
Patent Number: 5135915This is a patent covering the de-immunization of an organ by treatment with TGF-b before transplantation. The organs that may be used include heart, liver, spleen, pancreas, thyroid lobe, lung, kidney, intestine, blood vessel, and esophagus. The use of TGF bet to decrease immunogenecity is supported by other observations that this...
Human stem cells and monoclonal antibodies
Patent Number: 5130144This patent is similar to 5035994 and 4965204 by Civin. Essentially the current patent has 3 independent claims that cover similar subject matter as the other two mentioned patents. Specifically, "A method of transplanting stem cells comprising: (a) providing a suspension of human cells comprising pluripotent lympho-hematopoietic stem cells substantially free of mature lymphoid and...
Hair growth regulating composition comprising epithelium cell supernatant-derived growth factor
Patent Number: 5130142This patent teaches the production of a chemical composition useful for growing hair in bald people. The composition is made from media conditioned by growing epithelial cells. The composition is mitogenic to dermal papilla cells and 3T3 fibroblasts but not to epidermal cells. The molecular weight of the active ingredient is > 3 kDa.
Method for treating thrombocytopenia
Patent Number: 5126325This patent covers the use of B cell differentiation factor (BCDF) for treatment of thrombocytopenia. This may be interesting if the BCDF is still not characterized. It may be an interesting new way of stimulating hematpoietic stem cells to preferentially go towards the path of a specific lineage. I do have a feeling, however that the BCDF... This invention covers the synthethized form of a tetrapeptide that inhibits bone marrow stem cell entery into cell cycle. The original inhibitory activity was derived from fetal calf bone marrow as a biological "soup" but in this patent synthesis and structure are revealed. The use of agents that inhibit stem cell entry into cell cycle could occur when chemotherapy or radiation is... This patent covers the use of the stem cell antigen (SCA-1) for determination of murine hematopoieitic stem cells. The patent has 1 independent claim that covers "A cell composition consisting essentially of as the cellular population viable murine hematopoietic Sca-1+ stem cells from a genetically identical or congenic source."
Tetrapeptide inhibiting the entry into cycle of hemopoietic stem cells processes for its preparation, and its uses
Patent Number: 5114926
Homogeneous mammalian hematopoietic stem cell composition
Patent Number: 5087570