Patents
Method for stimulating transplanted bone marrow cells
Patent Number: 5187193This patent teaches the in vivo use of dithiocarbamate for hematopoietic reconstitution after bone marrow transplantation or myelosuppression. The dithiocarbamate or its analogs that are mentioned in the patent may be administered systemically without adverse effects.
Inventors: Borch, Richard F. (Pittsford, NY); Schmalbach, Therese K. (Newton, MA)
Assignee: University of Rochester (Rochester, NY)
Date of First Priority Issue: Monday September 12th, 1988
Composition and method for supporting bone marrow transplantation
Patent Number: 5186931This patent provides a composition of cytokines for stimulating hematopoiesis after a bone marrow transplant, as well as for the in vitro stimulation of hematopoiesis. The composition involves B cell differentiation factor and some commonly used cytokines today.
Inventors: Kishimoto, Tadamitsu (Nakano Tondabayashi-shi, Oosaka-fu, JP); Hirano, Toshio (Ibaraki, JP); Akiyama, Yukio (Kawasaki, JP); Okano, Akira (Kawasaki, JP); Matsui, Hiroshi (Kawasaki, JP); Takahara, Yoshiyuki (Kawasaki, JP)
Assignee: Ajinomoto Co., Inc. (Tokyo, JP) Kishimoto, Tadamitsu (Tondabayashi, JP)
Date of First Priority Issue: Wednesday August 6th, 1986
Preparation of pure cultures of post-mitotic human neurons
Patent Number: 5175103This patent covers one of the few stem cell therapies that actually entered clinical trials. The patent is for a teratocarcinoma cell line that is induced to differentiate into neurons with retinoic acid (and/or other factors) and then stops proliferating and can be used for cell therapy in stroke. The technology was eventually developed clinically by Layton Biosciences. Administration of the...
Inventors: Lee, Virginia (Philadelphia, PA); Pleasure, Samuel (Philadelphia, PA)
Assignee: Trustees of University of Pennsylvania (Philadelphia, PA)
Date of First Priority Issue: Monday October 21st, 1991
Propagatable, new combinant cells for cellular replacement therapy
Patent Number: 5175004This is a very interesting patent for generation of new cells and new stem cells. This patent is way ahead of its time. It teaches to take recipient cells from a degenerated organ, "rejuvenate" the cells by transplanting the nucleus of the old cell into a cytoplasm of a newer cell, generating a histocompatible cell population through this fusion, and transplanting the cells back into a...
Inventor: Matsumura, Kenneth N. (Berkeley, CA)
Assignee: None Stated
Date of First Priority Issue: Tuesday December 27th, 1988
Apparatus for removing fluid from an umbilical cord
Patent Number: 5171527This patent provides a medical device for rapidly extracting cord blood from an umbilical cord. This may be useful for collection of cord blood stem cells, which is a common practice in current medicine.
Inventors: Knippscheer, Hermann (Baldwin, NY); Richard, Daniel D. (Sedona, AZ)
Assignee: Cryo-Cell International, Inc. (Baldwin, NY)
Date of First Priority Issue: Friday January 26th, 1990
Method for stimulating production of bone marrow cell growth factors using dithiocarbamates
Patent Number: 5169765This patent teaches that dithiocarbamate and its analogues have the ability to stimulate bone marrow production of hematopoietic growth factors. Dithiocarbamate may be used according to the invention for stimulation of hematopoietic cells to produce growth factors, and subsequently the dithiocarbamate may be taken off the cells. While this patent seems like a really interesting method of...
Inventors: Borch, Richard F. (Pittsford, NY); Schmalbach, Therese K. (Newton, MA)
Assignee: University of Rochester (Rochester, NY)
Date of First Priority Issue: Tuesday September 12th, 1989
Method of treating hematologic diseases and pharmaceutical composition to be used therefor
Patent Number: 5166180This patent teaches ways to increase hematopoiesis through administration of some chemical compositions. The patent has 2 independent claims that essentially cover these compositions. This seems like an interesting patent but I need to actually look up and see if these compositions have been developed or not.
Inventor: Jenkins, Vernon K. (Houston, TX)
Assignee: Duphar International Research B.V. (Weesp, NL)
Date of First Priority Issue: Tuesday November 1st, 1988
In vitro propagation of embryonic stem cells
Patent Number: 5166065This patent was used to argue that the WARF patents were anticipated. The patent has two independent claims. The first covering a method of isolating embryonic stem cells, and the second covering a method of maintaining embryonic stem cells. Both independent claims use leukemia inhibitory factor to allow for the ex vivo growth of stem cells without loss of pluripotency.
Inventors: Williams, Robert L. (Warrandyte, AU); Gough, Nicholas M. (North Balwyn, AU); Hilton, Douglas J. (Warrandyte, AU)
Assignee: Amrad Corporation Limited (Kew, AU)
Date of First Priority Issue: Friday April 8th, 1988
Method for the treatment of grafts prior to transplantation using TGF-.beta .
Patent Number: 5135915This is a patent covering the de-immunization of an organ by treatment with TGF-b before transplantation. The organs that may be used include heart, liver, spleen, pancreas, thyroid lobe, lung, kidney, intestine, blood vessel, and esophagus. The use of TGF bet to decrease immunogenecity is supported by other observations that this molecule inhibits expression of MHC, which is one of the...
Inventors: Czarniecki, Christine W. (San Francisco, CA); Palladino, Michael A. (Foster City, CA); Shefter, Eli (San Francisco, CA)
Assignee: Genentech, Inc. (South San Francisco, CA)
Date of First Priority Issue: Friday October 14th, 1988
Human stem cells and monoclonal antibodies
Patent Number: 5130144This patent is similar to 5035994 and 4965204 by Civin. Essentially the current patent has 3 independent claims that cover similar subject matter as the other two mentioned patents. Specifically, "A method of transplanting stem cells comprising: (a) providing a suspension of human cells comprising pluripotent lympho-hematopoietic stem cells substantially free of mature lymphoid and myeloid...
Inventor: Civin, Curt I. (Baltimore, MD)
Assignee: The Johns Hopkins University (Baltimore, MD)
Date of First Priority Issue: Saturday June 2nd, 1984