Patents
Process for replicating bone marrow in vitro and using the same
Patent Number: 4721096This patent is broad reaching in that it covers the ex vivo expansion of bone marrow for treating a pateint whose bone marrow has been comprised. Essentially, this patent was ahead of its time since numerous companies are trying to perform this process even today. Essentially the patent's since independent claim covers extraction of bone marrow, ex vivo replication so that hematopoietic...
Inventors: Naughton, Brian A. (Yorktown Heights, NY); Naughton, Gail K. (Yorktown Heights, NY)
Assignee: Marrow-Tech Incorporated (Albany, NY)
Date of First Priority Issue: Friday April 18th, 1986
Human stem cells
Patent Number: 4714680This is one of the most important patents in the history of stem cell IP. It essentially covers the hematopoietic CD34+ stem cell. The patent has 3 independent claims, the first covering a population of hematopoietic cells in general, the second covering hematopoietic cells from blood, and the third covering hematopoietic cells which are recognized by a specific antibody, whose target was...
Inventor: Civin, Curt I. (Baltimore, MD)
Assignee: The Johns Hopkins University (Baltimore, MD)
Date of First Priority Issue: Saturday June 2nd, 1984
Primary bioassay of human tumor stem cells
Patent Number: 4411990Cancer stem cells have been known to exist for decades, as seen by the present patent whose actual first priority date is july 7, 1978. Unfortunately, research into cancer stem cells is only recently gaining attention. The cancer stem cell is the populatin which some believe is responsible for maintaining the tumor mass, while the other 99% of cancer cells are differentiated and have...
Inventors: Salmon, Sydney E. (Tucson, AZ); Hamburger, Anne W. (Potomac, MD)
Assignee: University Patents, Inc. (Norwalk, CT)
Date of First Priority Issue: Tuesday January 1st, 1980
Enhanced growth medium and method for culturing human mammary epithelial cells
Patent Number: 4423145This patent covers ways of growing mammary epithelial tissue in vitro. It teaches that such cells can be grown through dissociating stromal cells using enzymez and mechanical means so as to obtain a population of clumps of epithelial cells. The epithelial cells are then grown in a conditioned media that is either conditioned by human fetal intestine epithelial cells or human bladder epithelial...
Inventors: Stampfer, Martha R. (Oakland, CA); Smith, Helene S. (Oakland, CA); Hackett, Adeline J. (Orinda, CA)
Assignee: Unknown Assignee(s)
Date of First Priority Issue: Sunday July 5th, 1981
Method for producing substance capable of stimulating differentiation and proliferation of human granulopoietic stem cells
Patent Number: 4342828This patent teaches how to make a hematopoietic-stimulatory substance through taking out blood, extracting monocytes and macrophages, culturing them with a glycoprotein from urine, and collecting/concentrating the resulting composition, which is useful for stimulating the proliferation and differentiation of human granulopoietic stem cells. This may be an interesting way to generate growth...
Inventors: Takaku, Fumimaro (Utsunomiya, JP); Ogasa, Katsuhiro (Yokohama, JP); Kuboyama, Morio (Tokyo, JP); Yanai, Nobuya (Tokyo, JP); Yamada, Muneo (Kodaira, JP); Watanabe, Yoshiteru (Tokyo, JP)
Assignee: Morinaga Milk Industry Co., Ltd. (Tokyo, JP); The Green Cross Corp. (Osaka, JP)
Date of First Priority Issue: Friday July 20th, 1979
Method of expanding hematopoietic stem cells, reagents and bioreactors for use therein
Patent Number: 5,728,581This patent provides bioreactors and specific culture conditions for the in vitro and ex vivo expansion of hematopoietic stem cells. The patent discloses cytokines, oxygen tensions, and nutrients useful for expansion of cells.
Inventors: Schwartz, Richard Merrill (San Mateo, CA); Tucker, Sean Newton (San Francisco, CA); Chary, Srikanth Ranga (Fremont, CA); Kuo, Suzanne Chang (Cupertino, CA)
Assignee: Systemix, Inc. (Palo Alto, CA)
Date of First Priority Issue: Tuesday January 1st, 1980