Patents
Telomerase promoters sequences for screening telomerase modulators
Patent Number: 7,378,244Division of most mammalian cells is accompanied by reduction in the length of telomeres, which is responsible in part for cellular senescence and death. Some cells, particularly stem cells and cancer cells, express the enzyme telomerase and are not restricted by the "Hayflick Limit". Some data exists to support the concept...
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Isolation and expansion of human marrow stromal cells
Patent Number: 7,374,937This patent covers methods of expanding bone marrow stromal cells by culture at low concentrations. The stromal cells described in the patent are very similar in morphology and marker profile to mesenchymal stem cells that are already in clinical trials.
Methods disclosed by the patent include ways of inducing proliferation of isolated human bone marrow stromal cells by culturing...
Methods and compositions for nerve regeneration
Patent Number: 7,374,760Stem cell therapy has successfully been used in various animal models of neurodegenerative diseases including cerebral palsy, demyelinating conditions, and ALS. Stem cells in many situations do not need to differentiate into the cell of therapeutic interest to mediate effects but may simply provide...
In vivo synthesis of connective tissues
Patent Number: 7,375,077The current invention teaches the generation of connective tissue in vivo. Specifically, stem cells that have been differentiated into connective tissue cells, such as fibroblasts, are placed in a scaffold, with two other scaffolds surrounding the scaffold containing the cells. The two other scaffolds on the top and the bottom of the middle scaffold contain growth factors and...
Propagation and/or derivation of embryonic stem cells
Patent Number: 7,371,573This patent covers methods of growing embryonic stem cells outside of the body using novel tissue culture media and media additives.
Specifically, it covers the use of compounds that inhibit MEK-1 and/or MEK-2, as well as compounds that activate gp130 for use in stem cell propagation. This claim conceptually blocks anyone from using compounds known and unknown that modulate...
Nuclear transfer with porcine embryonic stem cells
Patent Number: 7,371,922This patent covers methods of making genetically engineered pigs. This is an important area of study not only from a research perspective, but also that transgenic animals may be used for things such as: a) mass production of proteins; b) donor organs for humans; and c) agricultural purposes.
The patent teaches the generation of pigs by:
1. Obtaining a pig ES cell...
CD56 positive human adult pancreatic endocrine progenitor cells
Patent Number: 7,371,576The quest for a stem cell therapy for diabetes has led to the evaluation of numerous cellular sources ranging from embryonic stem cells, to bone marrow derived stem cells, to mesenchymal stem cells. One interesting method of expanding insulin producing cells is through extraction of pancreatic...
Three dimensional bioengineered smooth muscle tissue and sphincters and methods therefor
Patent Number: 7,368,279This patent covers methods of producing artificial sphincters. Specifically, smooth muscle cells are grown on an extracellular matrix that is placed on a tissue culture vessal coated with polydimethyl siloxane and a mold made of a cylindrical shape which is coated with the same material. Examples of extracellular matrices useful for the invention include fibrin. The patent...
Method of enhancing neural stem cell proliferation, differentiation, and survival using pituitary adenylate cyclase activating polypeptide (PACAP)
Patent Number: 7,368,115Pharmaceutical activation of stem cells is arguably the next major revolution in medicine. The current patent is assigned to a Canadian stem cell company, Stem Cell Therapeutics (TSX-V:SSS), which already has entered Phase II clinical trials with pharmaceutical activators of endogenous stem cells for the treatment of stroke. While the ongoing clinical work of Stem Cell Therapeutics involves...
Multi-lineage directed induction of bone marrow stromal cell differentiation
Patent Number: 7,364,900This patent covers a 2 step method of generating insulin producing cells.
According to the first issued claim, the initial step involves obtaining what essentially appears to be a mesenchymal stem cell (adherent cell positive for CD44, CD90 and CD71, negative for monocyte and hematopoietic markers, CD11b and CD45, respectively) and culturing them with an antioxidant in order to generate...