Patents
Musculo-skeletal implant having a bioactive gradient
Patent Number: 7,351,423It is known that stem cells migrate towards injured tissue in response to chemotactic gradients. For example the basal SDF-1 gradient made by bone marrow stromal cells is why it is possible to achieve hematopoietic reconstitution by injecting donor cells intravenously. Similarly, SDF-1 acts as a gradient to call stem cells into damaged myocardium after a... This patent covers a new method of cloning cows. Specifically, the patent teaches a method of making a cow blastocyst by - extracting a primordial gamete cell population from the cow fetus The positive effects of stem cells in cardiac conditions is supported by many clinical trials. Efficacy has been demonstrated by both intracoronary administration, as well as intravenous administration of bone marrow and mesenchymal stem cells, respectively. In this patent, Medronics was granted some pretty far-reaching claims. This is a representative claim "A... This patent covers a "method of treating a mammal suffering from a hematopoietic disorder wherein bone marrow transplantation is required" through the administration of bone marrow cells and a bone matrix. The patent is interesting since it covers into only administration into the bone but also in sites outside of the bone. The patent covers various additives that can be... This patent covers a way of "controlling or inhibiting blastoma cancer cell proliferation in a mammal" by vaccinating with tumor cells that express the Streptococcus pyogenes gene emm55. The natural function of emm55 appears to be in immune evasion of the complement system. Since tumor cells have mammalian complement inhibitory proteins, maybe the approach proposed by... Corneal transplants are performed as a result of chemical or inflammatory injury to the clear part of the eye. Efficacy of corneal transplantation is decreased when the limbal stem cells which produce corneal epithelium are damaged or defective. Accordingly, transplantation of limbal stem cells has been performed clinically. A report in 1999 documented... This patent covers the composition of matter for novel compounds that are useful for modulation of sirtuins. Sirtuins are a class of proteins that act as histone deacetylase inhibitors. Why there is great interest in modulating these enzymes is because the SIR2 members of this family have been demonstrated to play a critical role in life extension associated with... This patent covers methods of expanding hematopoietic stem cells and their progenitors. The methods induce expansion but not differentiation of the cells. Essentially the patent teachs that expansion can be achieved by culture in media containing an "effective amount of TEPA-Cu chelate". TEPA stands for tetraethylenepentamine... One of the regenerative cells of the muscle is the myoblast. These cells essentially act as muscle stem cells, having the ability to multiply after injury and form muscle by fusing with other myoblasts. Myoblasts are very practical for cell therapy since they may be easily extracted from autologous sources and grown in vitro. Additionally, there is some evidence that myoblasts, upon fusing... One of the major technological advances that allowed for the characterization and use of stem cells was the development of defined monoclonal antibodies that repeatedly attached to markers on stem cells. For example, the patents covering the original hematopoietic stem cells used monoclonal antibodies to actually identify the...
Efficient nuclear transfer with primordial gametes
Patent Number: 7,351,876
- using the nucleus of the primordial gamete cell as a nuclear donor for an enucleated oocyte
- and activating the combination of the primordial gamete nucleus with the recipient... 
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Myocardial stimulation
Patent Number: 7,349,740
Methods of treatment of hematopoietic disorders
Patent Number: 7,347,999
Antigen modified cancer cell vaccines for cancer therapy
Patent Number: 7,348,015
Method for expansion of epithelial stem cells
Patent Number: 7,347,876
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Sirtuin modulating compounds
Patent Number: 7,345,178
Methods of expanding stem and progenitor cells and expanded cell populations obtained thereby
Patent Number: 7,344,881
Myoblast therapy for cosmetic treatment
Patent Number: 7,341,719
Anti-CD33 antibodies and method for treatment of acute myeloid leukemia using the same
Patent Number: 7,342,110