Patents
Buffy coat tube and float system and method
Patent Number: 7,329,534This patent covers a device that is capable of separating various cellular populations, or populations of particulate matter. Essentially, the device addresses the need for an easy to use, effective, and rapid method of collecting the "buffy coat" from a blood population, as well as cells within the buffy coat. The device purifies the cells using axial expansion of blood fluid components...
Modulation of cell fates and activities by phthalazinediones
Patent Number: 7,326,690This patent covers a pharmaceutical agent, and numerous derivatives thereof, for manipulation of cellular and stem cell activity. The family of compounds covered are called phthalazinediones, and they have previously been described to possess various anti-inflammatory activities. The patent claims include methods of treatment for metabolic diseases and methods of decreasing metabolic...
Decellularized bone marrow extracellular matrix
Patent Number: 7,326,571Numerous patents have been filed on de-cellularized tissues for use as matrices. For example, patent # 6,696,074 teaches that various fetal tissues may be de-cellularized and used as scaffolds. Such scaffolds may be seeded with various differentiated or stem cells, such as
Endoderm cells from human embryonic stem cells
Patent Number: 7,326,572This is one of Geron's numerous patents covering not only composition of matter for various stem cells (licensed from WARF) but also methods of actually differentiating the cells into different other cells that are useful either potentially for therapy or for research use. The current patent covers generation of endoderm through culturing of ES cells with Activin...
Methods and compositions for healing and repair of articular cartilage
Patent Number: 7,323,445This patent covers the regeneration of articular cartilage by administering an osteochondral graft together with purified bone morphogenetic protein (BMP) selected from the group consisting of BMP-2, 4, 5, 6, and 7 and one protein which induces the formation of tendon or ligament tissue selected from the group consisting of BMP-12,
Gene transfer into primate embryonic stem cells using VSV-G pseudotyped simian immunodeficiency virus vectors
Patent Number: 7,323,337This patent covers methods of transfecting embryonic stem cells. Specifically, it claims the use of SIV genetically engineered so that the nucleic acid which is being transfected is packaged into an SIV virion. Specific proteins and strains of SIV are covered that are useful for transfection. Numerous...
Cell delivery system comprising a fibrous matrix and cells
Patent Number: 7,323,190The current patent covers the delivery of cells using a matrix that is fibrous and the fibers are between 10 nanometers to 1 micrometer in diameter. The fibers are made in such a manner so that they are in contact with the cells. In some of the claims the fibers are comprised of polymers, one type of polymer covered is a linear aliphatic polyester. A specific type of linear aliphatic...
Production of pancreatic islet cells and delivery of insulin
Patent Number: 7,323,165Numerous approaches have been patented on the treatment of diabetes through regeneration. These range from bone marrow stem cell modification and administration, to generation of islets from embryonic stem cells, to creation of differentiated proliferating
Unactivated ungulate oocytes to produce a cloned ungulate by nuclear transfer
Patent Number: 7,321,076This patent is of the same family as the original patents on cloning by Dr Wilmut's group. Essentially the patent's overall main claim is represented in the first independent claim which states: Cloning an ungulate comprising: (i) fusing a diploid, ungulate differentiated cell with an unactivated, enucleated metaphase II-arrested oocyte of the same species to reconstruct an embryo; (ii...
Serial nuclear transfer of ungulate embryos
Patent Number: 7,321,075This patent covers a method of cloning in which the nucleus is transferred across generations. The first claim exemplifies the basis of what is covered, which is essentially "serial nuclear transfer" by a) taking a transgenic nucleus b) culturing the nucleus in an embryo c) splitting the embryoin into cells d) taking the nucleus from the cells and using it to insert into oocytes in order...