Human stem cells and monoclonal antibodies

Patent Number: 5130144

This patent is similar to 5035994 and 4965204 by Civin. Essentially the current patent has 3 independent claims that cover similar subject matter as the other two mentioned patents. Specifically, "A method of transplanting stem cells comprising: (a) providing a suspension of human cells comprising pluripotent lympho-hematopoietic stem cells substantially free of mature lymphoid and myeloid cells, having the ability to restore the production of lymphoid and hematopoietic cells in a patient where such production is lacking; and (b) administering said cell suspension to a human patient in an amount effective to effect such restoration." for the first independent claim. The second "A method of transplanting stem cells, comprising: (a) providing a suspension of human stem cells comprising pluripotent lympho-hematopoietic stem cells substantially free of mature lymphoid and myeloid cells, said suspension having the ability to restore the production of lymphoid and hematopoietic cells to a human lacking said production; and (b) administering said cell suspension to a human patient in an effective amount; wherein said suspension of human cells is substantially free of cells without a cell-surface antigen recognized by the monoclonal antibody produced by the hybridoma deposited under ATCC Accession No. HB-8483." and the third "A method of transplanting stem cells, comprising: (a) providing a suspension of human cells from marrow or blood comprising cells having a cell-surface antigen recognized by the antibody produced by the hybridoma deposited under ATCC Accession No. HB-8483 and substantially free of cells that do not have a cell-surface antigen recognized by said antibody, said suspension having the ability to restore the production of lymphoid and hematopoietic cells to a human lacking said production; (b) administering said cell suspension to a human patient in an effective amount."

View this patent on the USPTO website.