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Patents (1436 Stem Cell Patents)

Mesenchymal precursor cell

Patent Number: 7,399,632

Date of First Priority Issue: Tuesday July 15th, 2008
Date Issued: Wednesday July 7th, 1999
Assignee: Angioblast Systems, Incorporated (New York, NY)
Inventors: Simmons; Paul (East Melbourne, AU), Zannettino; Andrew (Adelaide, AU), Gronthos; Stan (Bethesda, MD)

From Class: Type

Mesenchymal stem cell therapy is rapidly becoming a clinical reality.  The beauty of this cell population is that it can be used in an "off the shelf" manner and does not appear to have many safety issues.  Mesenchymal stem cells from the bone marrow have been patented by Osiris, whereas cells similar to mesenchymal stem cells have been found in other tissues, for example in the cord blood and most interestingly by Medistem Inc in the menstrual blood called Endometrial Regenerative Cells.

The current patent covers "mesenchymal precursor cells", well actually a method of preparing them.

The patent has 1 independent claim that covers a method of preparing mesenchymal precursor cells by selecting for cells that express the marker STRO-1.  Dependent claims include, intra alia, markers such as LFA-3, ICAM-1, PECAM-1, P-selectin. L-selectin, CD49b/CD29, CD49c/CD29, CD49d/CD29, CD29, CD18, CD61, 6-19, thrombomodulin, telomerase, CD10, CD13, integrin beta, and SCF, as well as various concentrations of expression of STRO-1 and various properties of the cells.

It is interesting that specific sources of the mesenchymal stem cell are not mentioned in the independent claim, therefore the "mesenchymal precursor" if it contains the markers cited in the claims, regardless of origin, is infringing on this patent.

View this patent on the USPTO website.

Added to StemCellPatents.com on Sunday July 20th, 2008

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2 Comments | Add Comment

jonnyboy said...

Created 2008-07-31 03:23:28 EST
What is the difference between this one and osiris's?  Im no patent lawyer or even expert but it seems like these are the same cells.  They both come from the bone marrow, they both has similar properties, they are both mesenchymal, and they both express for the most part certain markers. 
- 1 -

Christineball33 said...

Created 2009-03-04 10:44:16 EST
Angioblast has a population, or maybe better said, a sub-population of osiris's
- 2 -

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