Leptin Blocks T Regulatory Cell Expansion

This video describes a publication teaching the use of antileptin antibody to augment proliferation of T regulatory cells.  The T regulatory cells is a specific component of the immune system that is activated by mesenchymal stem cells and has been associated with suppression of autoimmunity.  Essentially the video provides a... [Read more]

Mechanism of Multiple Sclerosis Stem Cell Therapy

Cleveland, Ohio -

A recent study (Bai et al. Human bone marrow-derived mesenchymal stem cells induce Th2-polarized immune response and promote endogenous repair in animal models of multiple sclerosis. Glia. 2009 Aug 15;57(11):1192-203) asked the question of whether human mesenchymal stem cells may be useful in the treatment of the mouse model of multiple... [Read more]

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Lithium for Treatment of Multiple Sclerosis

This video describes a publication which used the experimental allergic encephalomyelitis model of multiple sclerosis to test immunological effects of lithium.  The authors demonstrated profound inhibition of disease, as well as stimulation of antiinflammatory cytokines.  It seemed like the anti-inflammatory effects of lithium were associated with the... [Read more]

Treatment of Degenerative Disc Disease by Bone Marrow Stem Cells

Degenerative disc disease is a major problem, causing billions of dollars in lost work and medication.  Patents such as # 6,723,335 cover the use of stem cell injection into the nucleus pulposus of the disc in order to stimulate regeneration.  In a recent paper (Yang et al. Mesenchymal Stem Cells Arrest Intervertebral Disc Degeneration Through... [Read more]

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Apoptotic Cells Secrete Angiogenic Factors

It is a medical mystery why approaches such as extracorporeal ozone therapy or even photopheresis seem to have therapeutic effects in certain situations.  One possibility is that stressing of cells outside of the body causes formation of apoptotic bodies, with the apoptotic bodies having a therapeutic effect.

The possibility of apoptotic bodies... [Read more]

Hair Stem Cells for Injured Nerves

Sagamihara, Japan -

Hair follicle stem cells have previously been demonstrated to possess various characteristics of other stem cells, including migration to SDF-1, thus potentially allowing intravenous injection.  Also this stem cell population has been proposed, along with adipose stem cells, to have immune... [Read more]

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