Category: Use (79)

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Mechanism of Multiple Sclerosis Stem Cell Therapy

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Cleveland, Ohio -

A recent study (Bai et al. Human bone marrow-derived mesenchymal stem cells induce Th2-polarized immune response and promote endogenous repair in animal models of multiple sclerosis. Glia. 2009 Aug 15;57(11):1192-203) asked the question of whether human mesenchymal stem cells may be useful in the...

Friday July 24th, 2009 @ 13:04:52 EST 2 Comments

Treatment of Degenerative Disc Disease by Bone Marrow Stem Cells

Degenerative disc disease is a major problem, causing billions of dollars in lost work and medication.  Patents such as # 6,723,335 cover the use of stem cell injection into the nucleus pulposus of the disc in order to stimulate regeneration.  In a recent paper (Yang et al. Mesenchymal Stem Cells Arrest Intervertebral Disc Degeneration Through...

Thursday July 9th, 2009 @ 20:13:43 EST 2 Comments

Pulmonary Fibrosis Treated by Mesenchymal Stem Cells

Melbourne, Australia -

Systemic administration of stem cells is usually associated with preferential localization into the lung and liver.  Lung conditions such as acute respiratory distress syndrome have no cure with exception of transplantation, which is limited to a small number of patients.  The rationale of using mesenchymal stem cells for pulmonary diseases comes from...

Monday June 8th, 2009 @ 13:44:53 EST 1 Comment

Bone Marrow Stem Cells for Renal Failure

São Paulo, Brazil -

Bone marrow is classically known to be the site of hematopoiesis, thus "bone marrow transplant" has been successfully used for decades as a means of treating various hematological malignancies in which the recipient hematopoietic compartment is replaced by donor-derived stem cells.  More recent investigations have demonstrated that Monday December 22nd, 2008 @ 18:13:58 EST 6 Comments

Stressed Mesenchymals Make More IGF-1

New Orleans, Louisiana -

We at have been stating for a while now that one of the future areas of our field will be not simply determining if stem cell therapies work, but how to optimize them.  For example, bone marrow derived MSC are already in Phase III clinical trials, and numerous other cell based therapies are working their way...

Sunday November 30th, 2008 @ 20:53:23 EST

Caloric Restriction Stimulates Angiogenesis Through Adiponectin

Nagoya, Japan -

Caloric restriction is by far the most documented method of extending lifespan.  People have filed patents on methods of identifying compounds that induce biological effects similar to caloric restriction.  There are several theories as to how caloric restriction mediates its effects.  One interesting one is that it modulates...

Sunday November 16th, 2008 @ 12:57:10 EST

Angiogenesis requires endogenous stem cells

Nagoya, Japan -

Implantation of various stem cell populations into an ischemic muscle has been demonstrated to induce neovascularization both in animal studies, and in clinical trials.  Some people believe that the therapeutic angiogenesis may be occuring by differentiation of the stem cells injected into new endothelial...

Monday November 3rd, 2008 @ 21:47:44 EST

Allogeneic MSC for Restenosis

Naples, Italy -

The inherent antiinflammatory activities of mesenchymal stem cells have been leveraged for treatment of diseases associated with uncontrolled production of inflammatory mediators such as graft versus host disease and Crohn's Disease.  Indications for which mesenchymal stem cells are currently in Saturday August 16th, 2008 @ 21:32:06 EST

Go Cytori Go !

Tokyo, Japan -

One of the issues of adult stem cell therapy is processing.  When using allogeneic cells, for example, Endometrial Regenerative Cells, the cells can be made at a dedicated facility and shipped to where needed.  On the other hand, autologous cells present a little more difficulty since: a) people don't like having holes drilled in their...

Thursday June 26th, 2008 @ 02:15:55 EST 1 Comment

HGF-1 Double Blind Trial for Critical Limb Ischemia

Durham, NC -

Stimulation of angiogenesis has previously been demonstrated using various cell therapy methods, such as administration of autologous bone marrow stem cells either in the heart or ischemic leg muscle.  Autologous approaches sometimes are difficult since on the one hand they require cellular processing, which...

Monday June 23rd, 2008 @ 14:22:19 EST

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