Category: Hepatic (14)
Mouse Liver Failure Treated by Human Cord Blood Stem Cells
Sacramento, CA -
It is known that administration of autologous bone marrow cells into patients with liver failure induces clinical improvement, at least in pilot trials of cirrhotic patients. Mechanistically this may work through the process of transdifferentiation, that is, bone marrow directly differentiating to... London, UK- The use of stem cells to treat liver failure is not new. Animal models, as well as pilot clinical trials have demonstrated statistically significant improvement in liver enzyme values and overall clinical scores. In a recent study (Pai et al. Autologous Infusion of Expanded Mobilized Adult Bone Marrow-Derived... Shanghai, China - Liver failure is a major cause of moribidity and mortality, cited by some as the 7-10th largest cause of death. The possibility of stem cell therapy for liver failure is particularly attractive since intravenous administration of cells usually results in deposition into the liver. Animal studies have demonstrated that endogenous 
1 Comment
Clinical Trial of CD34 Stem Cells for Liver Failure
1 Comment
Stem Cells and Liver Failure
Serum Free ES to Hepatocyte Differentiation
Tehran, Iran - The ability to differentiate embryonic stem cells into various tissues would allow for the generation of tailor-made cells that could replenish damaged organs or cells of the organs. If one is to approach this field from the outside, it makes the most sense to start not be trying to build a whole new organ, which is comprised of many cell types, extracellular matrices, and...
Liver Failure Regeneration: Its the quality of the injury that matters
Houston, Texas- There are numerous clinical examples of adult stem cells helping people or animals with liver failure. One of the ways in which mesenchymal stem cells help in liver failure is by their ability to produce IL-10 in response to stellate cell generated IL-6...
4 Comments
Mesenchymal Stem Cells Talk with Hepatic Stellate Cells
Boston, MA - The ability of stem cells to inhibit progression of liver disease has been demonstrated in pilot human clinical trials. However the mechanisms by which bone marrow stem cell populations mediate antifibrotic effects are not completely known. In the mentioned clinical trial, administration of intravenous autologous bone...
Wnt/beta catenin in regenerating liver ! stem cells everywhere !
Pittsburgh, PA - The Wnt pathway is involved in tissue morphogenesis and has been found activated in various stem cell types and cancers. In a recent paper (Apte et al. Wnt/beta-catenin signaling mediates oval cell response in rodents. Hepatology. 2007 Oct 10) it was demonstrated that this pathway is activated in adult liver stem cells (oval cells) after liver damage. To induce liver...
CD133 is marker of liver stem cells
Los Angeles, CA - The liver is one of the most regenerative organs, with potential to reconstitute original mass even after 2/3 resection. It has been previously postulated that oval cells have stem cell-like ability and are involved in regeneration of liver after resection. In fact, it was even postulated that oval cells derived from the bone marrow (Oh et al. Bone marrow-derived...
Cord Blood and Bone Marrow Turning to Liver
[Watch the Video] Although liver failure is treated on an experimental basis with the use of bone marrow stem cells, not too many people are aware of the preclinical evidence supporting such an approach. The video describes the use of bone marrow stem cells, as well as cord blood stem cells, for the differentiation into hepatic-like cells after administration into recipients with carbon...
Clinical Evidence of Bone Marrow Therapy for Liver Failure
7 Comments