Category: Immunology (24)

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Leptin Blocks T Regulatory Cell Expansion

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This video describes a publication teaching the use of antileptin antibody to augment proliferation of T regulatory cells.  The T regulatory cells is a specific component of the immune system that is activated by mesenchymal stem cells and has been associated with suppression of autoimmunity.  Essentially the...

Sunday August 23rd, 2009 @ 04:23:26 EST

Apoptotic Cells Secrete Angiogenic Factors

It is a medical mystery why approaches such as extracorporeal ozone therapy or even photopheresis seem to have therapeutic effects in certain situations.  One possibility is that stressing of cells outside of the body causes formation of apoptotic bodies, with the apoptotic bodies having a therapeutic effect.

The possibility of apoptotic bodies...

Saturday June 27th, 2009 @ 03:54:59 EST

Free bone allograft prevents acute immune reaction

London, Canada -

Antibody-mediated acute vascular rejection (AVR) is a major problem in organ transplantation.  The C3H to BALB/c heterotopic (second heart) cardiac transplant model resembles the human condition of AVR.  When recipients are given a course of the conventionally used immune suppressant agent cyclosporin A, grafts survive 15 days.  This is approximately 8 days...

Tuesday May 26th, 2009 @ 22:40:47 EST 1 Comment

Medistem Fat Stem Cells Help Multiple Sclerosis Patients

San Diego, CA -

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Above is a video describing a recent publication, (Riordan et al, Non-expanded adipose stromal vascular fraction cell therapy for multiple sclerosis Journal of Translational Medicine 2009...

Rheumatoid Arthritis Model Treated by Mesenchymal Stem Cells

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Mesenchymal stem cells are of great interest due to their ability to be injected intravenously and home to the area of injury, as well as the fact that they do not require matching with the recipient.  To date, mesenchymal stem cells have been used in the treatment of Saturday March 14th, 2009 @ 04:19:50 EST 2 Comments

Radiation Induced Bacterial Translocation Causes GVHD

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When cord blood stem cells are used in the context of treatment of leukemia, graft versus host has been reported to occur in some patients.  Although incidence is reduced in patients who receive hematopoietic stem cells in the form of cord blood as compared to bone marrow, GVHD is still a concern.  An important question is why this does not seem to occur in...

Tuesday March 10th, 2009 @ 02:44:56 EST 1 Comment

Stem Cell Therapy for Multiple Sclerosis

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The use of stem cells for treatment of multiple sclerosis has the potential to address both the inflammatory aspects of the disease, as well as induce regeneration.  Above is a clip from a news release describing what appears to be a repeatedly successful treatment of multiple sclerosis using the...

Monday March 2nd, 2009 @ 20:41:36 EST

TNF alpha inhibits SDF-1 increases osteoclast precursors

Rochester, NY -

It is known that inflammatory mediators, such as interferon gamma, under chronic conditions are generally suppressive of hematopoiesis, whereas under acute conditions hematopoiesis is actually enhanced by inflammatory mediators. 

In a recent paper (Zhang et al. TNF inhibits production of stromal cell-derived factor 1 by...

Monday March 2nd, 2009 @ 02:17:27 EST

EPO Protects from Mouse Multiple Sclerosis

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New Jersey, USA -

There are many studies discuss immune modulation by stem cells by mechanisms such as IDO production, soluble HLA-G, and hepatocyte growth factor.  An interesting question is whether stimulators of various stem cell activities...

Thursday February 26th, 2009 @ 12:13:20 EST 1 Comment

Stem Cell Inhibition of Multiple Sclerosis by IDO Induction

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Lodz, Poland -

One of the very interesting things is trying to figure out how stem cells mediate their therapeutic effects in conditions such as multiple sclerosis.  In general there are three main ways: 1) Differentiation into neurons/oligodendrocytes; 2) Secrete growth...

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