G-CSF Stimulates Liver Repair

Wednesday August 8th, 2007 @ 10:43:28 EST

From Category: Differentiation
Comments: No comments

Rome, Italy -

G-CSF is clinically used to stimulate neutrophil production in patients who are neutropenic as a result of cancer therapy. Experimentally G-CSF is under investigation for mobilization of stem cells to help patients after cardiac infarct or stroke.

In a recent study (Piscaglia et al. Granulocyte-colony stimulating factor promotes liver repair and induces oval cell migration and proliferation in rats. Gastroenterology. 2007 Aug;133(2):619-31) the use of G-CSF in treatment of liver failure was investigated.

The scientists set up a model of liver regeneration by administration of 2-acetylaminofluorene and performance of partial hepatectomy in dipeptidyl-peptidase-IV-deficient female rats having wild-type male bone marrow.

The researchers found:

- Oval cells (considered a type of liver stem cell) expressed the G-CSF receptor

- G-CSF was produced endogenously in the process of liver regeneration

- Injection of exogenous G-CSF augmented oval cell proliferation

- The administration of G-CSF increased the contribution of bone marrow to liver repair

- In vitro G-CSF acts as a mitogen and a chemoattractant for oval cells

Social & Bookmarking:Digg 'G-CSF Stimulates Liver Repair' Add 'G-CSF Stimulates Liver Repair' to del.icio.us Add 'G-CSF Stimulates Liver Repair' to Technorati Stumble 'G-CSF Stimulates Liver Repair' Add 'G-CSF Stimulates Liver Repair' to Furl Add 'G-CSF Stimulates Liver Repair' to Reddit Add 'G-CSF Stimulates Liver Repair' to Blinklist Add 'G-CSF Stimulates Liver Repair' to Ma.gnolia Share 'G-CSF Stimulates Liver Repair' on Facebook Add 'G-CSF Stimulates Liver Repair' to Google Add 'G-CSF Stimulates Liver Repair' to Yahoo Web 

Add Comment

You must be signed-in to add your comments.

now or Join the StemCellPatents.com Community for free.

Home | News | Patents | Products | Jobs | Links | Search | Journal | RSS

About | Advisory Board | Newsletter | Advertise | Contact | Sitemap | Privacy Policy | Terms of Use

Copyright © 2006 - 2024 StemCellPatents.com - All rights reserved. - Toronto Web Design

StemCellPatents.com V2.04

Stouffville Concrete | Tottenham Concrete | Uxbridge Concrete | Gerogetown Concrete | Rockwood Concrete | Kleinburg Concrete | Stouffville Real Estate Agent