New Orleans, LA -
The use of adult stem cells for heart failure has previously been reported. What is interesting is the possibility of using autologous adult adipose derived stem cells for this condition. The beauty of adipose derived stem cells is, of course, that they are available in autologous settings in large numbers. Additionally, liposuction is a lot less painful than bone marrow aspiration.
Currently, the San Diego company Cytori is performing clinical trials using a closed system for collecting adipose stem cells, purifying mononuclear cells, and administering them into patients after a myocardial infarct.
In a recent study (Valina et al. Intracoronary administration of autologous adipose tissue-derived stem cells improves left ventricular function, perfusion, and remodelling after acute myocardial infarction. Eur Heart J. 2007 Oct 11) autologous adipose and bone marrow stem cells were compared in a porcine model of myocardial infarction.
Acute transmural infarcts were generated in pigs by inflation of an angioplasty balloon in the mid-left anterior descending artery for 3 hours followed by injection of 2 million stem cells.
The investigators found:
- Perfusion defect decreased approximately the same with bone marrow and fat stem cells.
- LVEF increased similarily between both bone marrow and fat stem cells
- Ventricular wall thickness was also increased similarly in bone marrow and fat stem cell treated groups
In conclusion the investigators found that bone marrow and fat stem cells had similar cardiac regenerative capabilities in a large animal infarct model.
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