G-CSF of Blood and Brain
Loma Linda CA-
We at StemCellPatents.com have described in various patents the relationship between hematopoietic stem cells and neural stem cells. Stunning examples include the ability of neurons to stimulate hematopoiesis, Patent # 6897060, the ability of the same hypoxic conditions that promote hematopoietic stem cell expansion to expand neural stem cells, Patent # 6924142, and the ability of neurons to transdifferentiate into hematopoietic stem cells, Patent # 6093531 .
In a review paper that appeared online today, Solaroglu et al discuss evidence that the clinically used cytokine G-CSF may be neuroprotective. The paper, entitled "Neuroprotective effect of granulocyte-colony stimulating factor" which appeared in Front Biosci. 2007 Jan 1;12:712-24 provides numerous animal model and theoretical examples as to why G-CSF administration may be useful in stroke.
The fact that G-CSF is already clinically tested for treatment of neurodegeneration in China supports the notion that there may be some rationale for this hypothesis.
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Michael said...
Do patients taking G-CSF for hematological malignancies have increases in mental function??