Leptin Blocks T Regulatory Cell Expansion

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This video describes a publication teaching the use of antileptin antibody to augment proliferation of T regulatory cells.  The T regulatory cells is a specific component of the immune system that is activated by mesenchymal stem cells and has been associated with suppression of autoimmunity.  Essentially the video provides a neat and easy to use method of expanding T regulatory cells.

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Mechanism of Multiple Sclerosis Stem Cell Therapy

July 24th, 2009

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Cleveland, Ohio -

A recent study (Bai et al. Human bone marrow-derived mesenchymal stem cells induce Th2-polarized immune response and promote endogenous repair in animal models of multiple sclerosis. Glia. 2009 Aug 15;57(11):1192-203) asked the question of whether human mesenchymal stem cells may be useful in the treatment of the mouse model of multiple sclerosis, experimental allergic encephalomyelitis (EAE). 

Mesenchymal stem cells are known to stimulate various shifts in immune response, due to a variety of soluble and membrane bound... [Read more] 2 Comments

Lithium for Treatment of Multiple Sclerosis

July 15th, 2009

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This video describes a publication which used the experimental allergic encephalomyelitis model of multiple sclerosis to test immunological effects of lithium.  The authors demonstrated profound inhibition of disease, as well as stimulation of antiinflammatory cytokines.  It seemed like the anti-inflammatory effects of lithium were associated with the inhibition of the enzyme GSK-3. 

Other treatments for multiple sclerosis that are experimental include fat stem cells, erythropoietin[Read more]

Treatment of Degenerative Disc Disease by Bone Marrow Stem Cells

July 9th, 2009

Degenerative disc disease is a major problem, causing billions of dollars in lost work and medication.  Patents such as # 6,723,335 cover the use of stem cell injection into the nucleus pulposus of the disc in order to stimulate regeneration.  In a recent paper (Yang et al. Mesenchymal Stem Cells Arrest Intervertebral Disc Degeneration Through Chondrocytic Differentiation and Stimulation of Endogenous Cells. Mol Ther 2009 Jul 7) the use of bone marrow stem cell injection into degenerating discs was assessed.

The stem cells used were bone... [Read more] 2 Comments

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