Methods and compositions for modulating sphingosine-1-phosphate (S1P) receptor activity

Patent Number: 7,241,812

It is known that Sphingosine-1-phosphate mediates migration of mesenchymal stem cells. However, there are numerous receptors by which the effects of sphingosine-1-phosphate are mediated. While the sphingosine-1-phosphate receptor 1 is associated with migration, other activation of other receptors (such as sphingosine-1-phosphate receptors 2-5) is associated with adverse events such as hypotension or bradycardia.

The current patent covers some novel compositions of matter that selectively modulate activity of sphingosine-1-phosphate receptor 1. The use of these compounds for treatment of autoimmunity, modulation of stem cell migration, and treatment of transplant rejection is also covered.

View this patent on the USPTO website.