Combined effects of nutrients on proliferation of stem cells

Patent Number: 7,442,394

Manipulation of the stem cell compartment using nutritional supplements offers a rapid way of commercially entering the area of regenerative medicine without having to undergo full-blown FDA clinical trials.  Examples of such patents include #7,338,676 which teaches extracts of pinecones can induce stem cell differentiation into dendritic cells, patent #7,419,690 covering the use of yam extracts to activate hematopoietic stem cells, or my personal favorite (sarcastic), #6,814,961 which covers the use of blue-green algae to mobilize stem cells, which was the basis for the multi-level marketing StemTech company.

The current patent covers two compositions of matter, as well as their use in increasing stem cell proliferation.  The first composition is described in the first claim, which is "A composition for stimulating stem cell proliferation comprising 400 mg to 25 grams of blueberry extract, 10 mg to 100 mg of carnosine, 400 mg to 25 grams of green tea extract and 2000 IU to 4000 IU of vitamin D.sub.3".  The second composition is described in the second claim, which is "A composition for stimulating stem cell proliferation consisting essentially of 400 to 25 grams of blueberry extract, 10 mg to 100 mg of carnosine, 400 to be 25 grams of green tea extract and 2000 IU of vitamin D.sub.3". 

The inventors went to some lengths to evaluate in vitro and in vivo the effects of their composition, including demonstration of in vitro augmentation of CD34 proliferation, and in vivo reduction in stroke volume.

View this patent on the USPTO website.