Mesenchymal stem cells for prevention and treatment of immune responses in transplantation
Patent Number: 6368636
Date of First Priority Issue: Wednesday March 18th, 1998
Date Issued: Tuesday April 9th, 2002
Assignee: Osiris Therapeutics, Inc. (Baltimore, MD)
Inventors: McIntosh, Kevin R. (Ellicott City, MD); Mosca, Joseph D. (Ellicott City, MD); Klyushnenkova, Elena N. (Baltimore, MD)
From Class: Use
Comments: No comments
This patent teaches the use of mesenchymal stem cells for preventing allograft rejection through immune modulation.
It is known that bone marrow cells can display a veto-like effect in that they are capable of inducing donor-specific tolerance. The bone marrow cells are one source of mesenchymal stem cells. In this patent purified mesenchymal stem cells are claimed not only for inducing donor-specific tolerance but also immune modulation to third-party antigens.
View this patent on the USPTO website.
Added to StemCellPatents.com on Monday October 16th, 2006
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