Category: Hematopoietic (26)
Embryonic to Mesenchymal Stem Cell Differentiation
Madison, Wisconsin - ES cells are very useful since they can be genetically modified to overexpress specific genes, or alternatively, specific genes can be deleted. In a recent publication (Trivedi et al. Simultaneous generation of CD34 primitive hematopoietic cells and CD73 mesenchymal stem cells from human embryonic stem cells...
Chromatin Modification for Hematopoietic Stem Cell Expansion
Chicago, Illinois - The ability to expand autologous hematopoietic stem cells ex vivo, while retaining hematopoietic reconstitutive activity in vivo would allow cell therapy for many types of leukemias and cancers in patients lacking donors. Unfortunately, to date, there has been very little success at ex vivo expansion of hematopoietic stem cells that can successful re-establish...
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Growth Hormone Double Blind Hematopoiesis Study
Surrey, UK – It is always nice to see patented concepts verified by scientific publications, especially when it is in clinical trials settings. Readers of StemCellPatents.com will know that US patent # 6348444 assigned to Applied Research Systems ARS Holding N.V. (A wholly...
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Stromal-Like Environment Critical to Stem Cell Expansion
St. Louis, MO-
It is long been suggested that the appropriate imitation of in vivo microenvironments is critical to successful culture, expansion, and differentiation of stem cells.
In a paper which appeared in the Nov 9 online issue of Blood (Cytokine and integrin stimulation synergize to promote higher levels of GATA-2, c-myb, and CD34... Durham, North Carolina
Chute et al reported today that administration of mouse endothelial cells to irradiated B6 recipients was capable of accelerating hematopoietic reconstitution after sublethal and lethal irradiation.
In a paper entitled "Transplantation of vascular endothelial cells mediates the hematopoietic recovery and survival of lethally irradiated mice" published in today's... London UK
One of the major limitations of stem cell transplantation is the need to overcoming allogeneic barriers. The generation of stem cells from already differentiated tissue would significantly revolutionize the area of stem cell therapeutics.
In a paper published today (Abuljadayel et al. Infusion of autologous retrodifferentiated stem cells into patients with beta-thalassemia...
Endothelial Stimulation of Hematopoietic Engraftment
Clinical Trial of “Retro-Differentiated” Stem Cells: A Novel Way to Generate Autologous Stem Cells