Category: Type (30)
Pluripotency in the amnion
Pittsburgh, PA - It has previously been described that anmiotic stem cells can be isolated and contain numerous regenerative properties. In a recent paper (Miki et al. Identification of stem cell marker-positive cells by immunofluorescence in term human amnion. J Reprod Immunol. 2007 May 8) the characterization of stem cells from...
CD55 as a marker of Cancer Stem Cells
Osaka, Japan - The search for tumor stem cells has revealed numerous markers that are present on non-tumor stem cells as markers of tumor stem cells. For example, the recent discovery that CD133 is found on colon cancer stem cells should not be a surprise, since this marker is also found on other types of stem cells. What
Stem Cells Getting Old
Iowa City, IA- Although autologous bone marrow is currently investigated clinically for numerous indications, one of the fears is that old stem cells may lose regenerative ability with age, and as a result be less effective as opposed to other stem cell sources such as cord blood. A recent publication (Zheng et al. Impact of aging on rat bone marrow-derived stem cell chondrogenesis. J...
Adult Neural Precursors for Parkinson's
Seoul, South Korea - Fetal cell therapy has been previously used in clinical trials for treatment of Parkinson's Disease, although with little success (Olanow et al. A double-blind controlled trial of bilateral fetal nigral transplantation in Parkinson's disease. Ann Neurol. 2003 Sep;54(3):403-14). It a recent paper (Shim et al. Generation of Functional Dopamine Neurons from Neural...
1 Comment
Amniotic Stem Cells: Old News
Winston-Salem, North Carolina - Readers of StemCellPatents.com are familiar with the fact that amniotic fluid contains stem cells with pluripotent activity useful for numerous applications, including regeneration of cartilage. A press release that made national...
CAR cells drive hematopoiesis
Kyoto, Japan - It is an established fact that administration of bone marrow hematopoietic cells systemically leads to their homing to the recipient bone marrow due in part to constitutive secretion of the cytokine SDF-1, otherwise known as CXCL12, by the bone marrow stroma. It is also known that tissue injury, whether by a pathological...
Glucocorticoid Inhibition of Skin Cancer
Chicago Illinois - Chebotaev et al reported today that overexpression of glucocorticoid receptor in the skin of mice inhibits carcinogenesis. The paper (The tumor suppressor effect of the glucocorticoid receptor in skin is mediated via its effect on follicular epithelial stem cells. Oncogene. 2006 Dec 4) provided evidence suggestive of the role of follicular epithelial stem...
Stem Cells Come in All Shapes and Sizes
Louisville, KY – Stem cells from adult sources (non-embryonic) are generally believed to be restricted in differentiation potential. However, there are several reports of stem cells from bone marrow and cord blood that express makers of pluripotency. For example, in 2004 Prockop’s group from Tulane reported that if one incubates early passaged human bone marrow derived mesenchymal...
Mesenchymal Stem Cells: The younger the better !
London, UK Guillot et al published in the Nov 22 edition of Stem Cells a paper entitled "Human first trimester fetal mesenchymal stem cells (MSC) express pluripotency markers, grow faster, and have longer telomeres compared to adult MSC." which suggests several advantages to regenerative uses of fetal derived mesenchymal stem cells as compared to the currently...
5 Comments
Colon Cancer Stem Cell Revealed
Toronto Canada - Researchers at Princess Margaret Hospital in Toronto published in todays journal Nature the identification of a cell population within the bulk tumour mass that possesses the functional characteristics of a tumor stem cell. In a paper entitled "A human colon cancer cell capable of initiating tumour growth in immunodeficient mice." John Dick's group essentially...
4 Comments