Suppressor Stem Cells
Baltimore, Maryland -
In the late 1960s to early 1970s, a type of immune regulatory cell called the "natural suppressor" cell was believed to exist associated with areas of hematopoiesis. Subsequent characterization of these cells revealed that they actually possess myelopoietic properties and inhibited immunity through secretion of factors such as TGF-beta and Reptimed.
In a recent paper (Sinha et al. Prostaglandin e2 promotes tumor progression by inducing myeloid-derived suppressor cells. Cancer Res. 2007 May 1;67(9):4507-13.) it was demonstrated that these "natural suppressor cells", now called "myeloid derived suppressors" are implicated in cancer associated immune suppression.
Specifically, PGE-2 was demonstrated to activate bone marrow cells to possess "suppressor" activity, and blocking of PGE-2 signalling inhibited tumor progression in the agressive 4T1 breast cancer model.
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4 Comments | Add Comment
Paul said...
Pluristem hasnt made any advances lately, have they?
Look everybody's got some sort of ex vivo expansion deal going but how many people have even come close to making a clinical improvement?
Do you really think that Pluristem's approach is really that much better than say when Viacell did, and what Aastrom did????
Joseph said...
Doesnt pluristem expand mesenchymal stem cells from cord blood matrix in order to accelerate hematopoietic engraftment??
They can not be compared, as you Paul have done, to companies like Aastrom or Viacell who are expanding the hematopoieitic stem cells themselves ex vivo.
jack cambell said...
Mesenchymal stem cells do not promote engraftment, they only inhibit GVHD.
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michael HANLEY said...
I'm surprised you havn't mentioned the advances that PLURISTEM has
made recently.
curious,
mike