Method for the treatment of grafts prior to transplantation using TGF-.beta .
Patent Number: 5135915
Date of First Priority Issue: Friday October 14th, 1988
Date Issued: Wednesday April 8th, 1992
Assignee: Genentech, Inc. (South San Francisco, CA)
Inventors: Czarniecki, Christine W. (San Francisco, CA); Palladino, Michael A. (Foster City, CA); Shefter, Eli (San Francisco, CA)
From Class: Use
Comments: No comments
This is a patent covering the de-immunization of an organ by treatment with TGF-b before transplantation. The organs that may be used include heart, liver, spleen, pancreas, thyroid lobe, lung, kidney, intestine, blood vessel, and esophagus. The use of TGF bet to decrease immunogenecity is supported by other observations that this molecule inhibits expression of MHC, which is one of the antigens recognized by the immune system when mediating graft rejection.
View this patent on the USPTO website.
Added to StemCellPatents.com on Monday October 16th, 2006
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