Production of megakaryocytes by the use of human mesenchymal stem cells

Patent Number: 7,153,500

This patent covers a method of increasing megakaryocytes (precursors of platelets) to patients that are deficient in these cells. Specifically, there are two claims to the patent. The first covers the increasing of megakarocyte numbers by administration of mesenchymal stem cells. The second covers a method of increasing megakaryocyte numbers through administration of CD34 stem cells together with mesenchymal stem cells.

The ability of mesenchymal stem cells to promote expansion of other hematopoietic lineages is known. Accordingly, this patent only adds more IP protection to the existing concept that Osiris has developed in terms of using allogeneic mesenchymal stem cells for treatment of patients that have been immune suppressed or myeloablated.

View this patent on the USPTO website.