Methods of using deacetylase inhibitors to promote cell differentiation and regeneration
Patent Number: 7,229,963
Date of First Priority Issue: Thursday October 18th, 2001
Date Issued: Tuesday June 12th, 2007
Assignee: United States of America as represented by the Secretary of the Department of of Health Services, National Institutes of Health (Washington, DC)
Inventors: Sartorelli; Vittorio (Bethesda, MD), Puri; Pier Lorenzo (San Diego, CA)
From Class: Expansion
Comments: No comments
The use of histone deacetylase inhibitors for inducing new gene expression of genes that are developmentally silenced is a very exciting method of "reactivating" stem cells. For example, the histone deacetylase inhibitor valproic acid is a clinically used agent that stimulates stem cell expansion.
The current patent teaches ways of using histone deacetylase inhibitors such as sodium butyrate, trichostatin A, or valproic acid for muscular degeneration including muscular dystrophy.
View this patent on the USPTO website.
Added to StemCellPatents.com on Saturday June 16th, 2007
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