Patents (1436 Stem Cell Patents)

Quantitative RT-PCR to AC133 to diagnose cancer and monitor angiogenic activity in a cell sample

Patent Number: 7,252,976

Date of First Priority Issue: Wednesday August 28th, 2002
Date Issued: Tuesday August 7th, 2007
Assignee: Board of Regents the University of Texas System (Austin, TX)
Inventors: Lin; Edward H. (Houston, TX), Wu; Xifeng (Pearland, TX), Xie; Keping (Pearland, TX)

From Class: Use
Comments: No comments

Based on the title, one would think that this patent covers global use of PCR amplifying for CD133 transcripts in order to detect angiogenic propensity in a host. If this were the case, then the patent indeed would be very strong.

The patent, however, is restricted to covering the diagnosis of colorectal cancer using PCR amplification of CD133 transcripts in peripheral blood.

This approach seems interesting since it is non-invasive and conceptually would allow one to "play around" with angiogenic modulators, and test the activity on circulating angiogenic precursors, BEFORE the tumor angiogenesis has progressed to the point where the tumor's actual clinical effects are felt.

View this patent on the USPTO website.

Added to StemCellPatents.com on Saturday August 11th, 2007

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