Process for producing nerve stem cells, motor neurons, and GABAergic neurons from embryonic stem cells
Patent Number: 7,294,510
Date of First Priority Issue: Friday March 30th, 2001
Date Issued: Tuesday November 13th, 2007
Assignee: Japan Science and Technology Corporation (Kawaguchi-shi, JP)
Inventors: Okano; Hideyuki (Tokyo, JP), Shimazaki; Takuya (Tokyo, JP)
From Class: Differentiation
Comments: No comments
This patent covers the generation of neurons through inducing embryonic stem cells to differentiate using the noggin protein and combinations of noggin with other factors. Noggin is an antagonist of bone morphogenic proteins and has been demonstrated to regulate numerous stem cell activities in vivo.
The patent essentially teaches the use of noggin and ES cells for:
- forming embryoid bodies
- producing neural stem cells
- producing motor neurons and GABAergic neurons
View this patent on the USPTO website.
Added to StemCellPatents.com on Sunday November 18th, 2007
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