Generating vascular smooth muscle cells in vitro from ES cells
Patent Number: 7,354,763
Date of First Priority Issue: Friday April 5th, 2002
Date Issued: Tuesday April 8th, 2008
Assignee: Technion Research & Development Foundation Ltd. (Haifa, IL)
Inventors: Gerecht-Nir; Sharon (Haifa, IL), Itskovitz-Eldor; Joseph (Haifa, IL)
From Class: Differentiation
Comments: No comments
This patent covers the generation of vascular smooth muscle cells from embryonic stem cells through specific culture conditions. In one embodiment the differentiation is induced through exposure to the cytokines TGF, angiopoietin, and platelet derived growth factor BB.
In the examples section the generation of SMA positive cells from embryonic stem cells is demonstrated, as well as various other smooth muscle characteristics of the newly created cells.
View this patent on the USPTO website.
Added to StemCellPatents.com on Sunday April 13th, 2008
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