This patent covers the inhibition of placental growth factor as a method of treating osteoporosis. The one issued claim is restricted to inhibition of placental growth factor using an antibody or fragments of the antibody.
The inventor demonstrated inhibition of bone resorption in an animal model, as well as in vitro using anti-placental growth factor antibodies. Interestingly in the examples the use of mesenchymal stem cells together with this antibody are also described.
View this patent on the USPTO website.
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Christineball33 said...