System for administering a combination of therapies to a body lumen

Patent Number: 6918869

This patent teaches ways of administering agents into the lumen of a body, agents including stem cell therapy. The patent seems to cover methods of administering agents in a manner that does not induce restenosis. The patent has 3 independent claims, which are:

A system for delivering a biologically active material to a surface of a body lumen exposed to a radioactive source comprising: (a) an implantable medical device having two opposing ends, a middle portion and a surface; and (b) at least one biologically active material applied to the ends of the medical device, wherein the middle portion is substantially free of any biologically active material; and wherein the biologically active material comprises a non-genetic therapeutic agent, a genetic material, a cell or a charged therapeutic agent, and is in a particulate form having an average particle size of about 1 to about 100 microns.

A system for delivering a biologically active material to a surface of a body lumen exposed to a radioactive source comprising: (a) an implantable medical device having two opposing ends, a middle portion and a surface; (b) a biologically active material incorporated into a first coating composition; and © a second coating composition comprising a second biologically active material, wherein the first and the second coating composition are disposed upon at least one end of the medical device; and the middle portion is substantially free of a biologically active material.

A system for delivering a biologically active material to a surface of a body lumen exposed to a radioactive source comprising: (a) an implantable medical device having two opposing ends, a middle portion and a surface; wherein the medical device comprises a catheter, a guide wire, a balloon, a filter, a stent, a stent graft, or a vascular graft; and (b) at least one biologically active material applied to the ends of the medical device; wherein the biologically active material is released upon application of the radioactive source, and wherein the middle portion is substantially free of any biologically active material.

View this patent on the USPTO website.